Journal of Natural Medicines

, Volume 72, Issue 2, pp 588–592 | Cite as

Reinereins A and B, new onocerane triterpenoids from Reinwardtiodendron cinereum

  • Alfarius Eko Nugroho
  • Daisuke Inoue
  • Chin Piow Wong
  • Yusuke Hirasawa
  • Toshio Kaneda
  • Osamu Shirota
  • A. Hamid A. Hadi
  • Hiroshi MoritaEmail author


Bioactivity guided separation of Reinwardtiodendron cinereum barks methanol extract led to the isolation of two new onocerane triterpenoids, reinereins A and B (1 and 2), together with three known onocerane triterpenoids. Their structures were elucidated on the basis of NMR spectroscopic data. In vitro cytotoxic activities of the isolated compounds against several type of cancer cells were evaluated.


Triterpenoid Onocerane Reinwardtiodendron cinereum Cytotoxicity Meliaceae 



This work was supported by Grants in-Aid for Scientific Research from JSPS, Japan.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Alfarius Eko Nugroho
    • 1
  • Daisuke Inoue
    • 1
  • Chin Piow Wong
    • 1
  • Yusuke Hirasawa
    • 1
  • Toshio Kaneda
    • 1
  • Osamu Shirota
    • 2
  • A. Hamid A. Hadi
    • 3
  • Hiroshi Morita
    • 1
    Email author
  1. 1.Faculty of Pharmaceutical SciencesHoshi UniversityTokyoJapan
  2. 2.Faculty of Pharmaceutical Sciences at Kagawa CampusTokushima Bunri UniversitySanukiJapan
  3. 3.Department of Chemistry, Faculty of ScienceUniversity of MalayaKuala LumpurMalaysia

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