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Journal of Natural Medicines

, Volume 72, Issue 2, pp 439–447 | Cite as

New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

  • Keiko Ogawa
  • Seikou Nakamura
  • Kohei Hosokawa
  • Hanako Ishimaru
  • Natsuki Saito
  • Kaori Ryu
  • Masahiro Fujimuro
  • Souichi Nakashima
  • Hisashi MatsudaEmail author
Original Paper

Abstract

Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.

Keywords

Nigella damascena Ranunculaceae Diterpene Antiviral activity HSV-1 

Notes

Acknowledgements

This research was supported in part by a Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Supported Program for the Strategic Research Foundation at Private Universities 2015–2019.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2017

Authors and Affiliations

  • Keiko Ogawa
    • 1
  • Seikou Nakamura
    • 1
  • Kohei Hosokawa
    • 1
  • Hanako Ishimaru
    • 1
  • Natsuki Saito
    • 1
  • Kaori Ryu
    • 1
  • Masahiro Fujimuro
    • 1
  • Souichi Nakashima
    • 1
  • Hisashi Matsuda
    • 1
    Email author
  1. 1.Department of PharmacognosyKyoto Pharmaceutical University, MisasagiKyotoJapan

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