Journal of Natural Medicines

, Volume 72, Issue 1, pp 20–31 | Cite as

Immunomodulatory constituents from Ascomycetous fungi

  • Haruhiro FujimotoEmail author
Review In memoriam to Professor Shoji Shibata: Pioneer in Modern Pharmacognosy


Our screening project, namely, search for new immunomodulatory constituents from Ascomycetous fungi, was guided by the effects on mitogen-induced proliferations of mouse spleen lymphocytes. On the project, the defatted crude extracts from Gelasinospora multiforis, G. heterospora, G. longispora, G. kobi, Diplogelasinospora grovesii, Emericella aurantio-brunnea, Eupenicillium crustaceum, etc., submitted to the solvent partition followed by fractionation with repeated chromatography monitored by immunomodulatory activity to afford many active constituents, of which molecular structures including absolute configurations and immunomodulatory activities were elucidated. All of these immunomodulatory constituents isolated on the project were practically not immunostimulants but immunosuppressants.


Screening Ascomycete Fungal metabolite Absolute structure Immunomodulatory assay Immunosuppressive activity 



I am very grateful to Prof. M. Yamazaki, Prof. M. Ishibashi and Dr. E. Okuyama of Chiba University, and also all other coauthors of our original papers cited in the references for their valuable discussion and kindly collaboration. I am also grateful to Prof. K. Kawai of Hoshi University for the gift of authentic samples of variecolin, variecolactone and variecolol, to Dr. T. Uegaki of Fujisawa Pharmaceutical Co., Ltd. (present name: Astellas Pharma Inc.) for the gift of authentic sample of tacrolimus (FK506), and to Mr. T. Okazaki and Ms. K. Nanaumi of Taisho Pharmaceutical Co., Ltd. for the cytotoxicity assay.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2017

Authors and Affiliations

  1. 1.ChibaJapan

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