Journal of Natural Medicines

, Volume 72, Issue 1, pp 364–368 | Cite as

Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.

  • Sanghoon Lee
  • Naonobu TanakaEmail author
  • Jun’ichi Kobayashi
  • Yoshiki KashiwadaEmail author


Two new diterpene alkaloids having an N-methyladenine moiety, agelamasines A (1) and B (2), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses. Agelamasine A (1) is the first diterpene alkaloid with a rearranged (4 → 2)-abeo-clerodane skeleton from a marine source, while agelamasine B (2) is a clerodane diterpene alkaloid.


Marine sponge Agelas sp. Diterpene alkaloid Rearranged clerodane Agelamasines A and B 



We thank Mr. Z. Nagahama for his help with the sponge collection. This work was partly supported by JSPS KAKENHI Grant number JP17K08337.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesTokushima UniversityTokushimaJapan
  2. 2.Graduate School of Bioscience and BioindustryTokushima UniversityTokushimaJapan
  3. 3.Graduate School of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

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