Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan
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Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC50 values: 2.14–2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC50 value: 5.99 µM) and A549 cells (IC50 value: 6.18 µM).
KeywordsPigeon pea Stilbene dimer Cyclobutane Cytotoxicity
This study was supported by the National Undergraduate Training Programs for Innovation and Entrepreneurship (No. 201610660024), Project of Health and Family Planning Committee of Guizhou Province (No. gzwjkj2014-2-103), Joint Fund of the Department of Science and Technology of Guizhou Province and Guizhou Medical University (No. LH 7339), and Fund of the Innovation Team of Guizhou Province (No. 2015-4025).
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Conflict of interest
The authors declare that they have no conflict of interest.
- 4.Sun SM, Sun YM, Liu J (1995) Studies on the pharmacology of cajanin preparation. Chin Tradit Herbal Drugs 26:147–148Google Scholar
- 14.Hoppe DC, Inman WD (2001) Methods of using stilbenoids to treat hyperglycemia and to reduce blood glucose levels. US Patent, 40–46Google Scholar