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Journal of Natural Medicines

, Volume 72, Issue 1, pp 202–210 | Cite as

Bioactive constituents from the whole plants of Leontopodium leontopodioides (Wild.) Beauv.

  • Qiu Chen
  • Jian Li
  • Jingya Ruan
  • Lu Qu
  • Hongyan Wei
  • Xiaoling Ma
  • Yi ZhangEmail author
  • Tao WangEmail author
Original Paper

Abstract

Five new compounds, leontoaerialosides A (1), B (2), C (3), D (4), and E (5) were obtained from the 70% EtOH extract of the whole plants of Leontopodium leontopodioides (Wild.) Beauv. Their structures were elucidated by chemical and spectroscopic methods. Moreover, compounds 4 and 5 showed significant effects on stimulating the hepatic glucose uptake in HepG2 cells.

Keywords

Leontopodium leontopodioides (Wild.) Beauv. Leontoaerialosides A–E HepG2 cells Glucose uptake assay 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose 

Notes

Acknowledgements

This work was financially supported by grants from the National Natural Science Foundation of China (31460081, 21405113), and the Important Drug Development Fund, Ministry of Science and Technology of China (2017ZX09305-002).

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  1. 1.Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjinChina
  2. 2.Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjinChina
  3. 3.Xinjiang Institute of Chinese Medicine and Medicine of NationalUrumqiChina

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