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Journal of Natural Medicines

, Volume 72, Issue 1, pp 127–135 | Cite as

Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells

  • Hye-Jin Park
  • Jun-Hyo Cho
  • Shin-Hyub Hong
  • Dong-Hee Kim
  • Hee-Young Jung
  • In-Kyu Kang
  • Young-Je ChoEmail author
Original Paper

Abstract

Ferulic acid isolated from Tetragonia tetragonioides was tested for its whitening effect on the B16F10 mouse melanoma cell line and its anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line. Ferulic acid, one of the primary phenolic compounds that can be isolated from T. tetragonioides, has been reported to show potential as a functional food, for its whitening effect and anti-wrinkle activity. To measure its whitening and anti-wrinkle activities, cells were treated with ferulic acid isolated from T. tetragonioides at concentrations between 5 and 20 μM. Ferulic acid showed no cytotoxicity at concentrations up to 20 μM. Ferulic acid inhibited melanin synthesis, tyrosinase expression, and microphthalmia transcription factor expression in B16F10 cells stimulated with α-melanocyte stimulating hormone. Ferulic acid induced procollagen synthesis, hyaluronic acid synthesis, tissue inhibitor of metalloproteinase synthesis, and inhibited matrix metalloproteinase (MMP)-1 and MMP-9 expression in CCD-986sk cells stimulated with UV-B. On the basis of these results, we conclude that ferulic acid isolated from T. tetragonioides shows potential for use as a functional food, with whitening and anti-wrinkle activities.

Keywords

Tetragonia tetragonioides Ferulic acid B16F10 mouse melanoma cells CCD-986sk human dermal fibroblasts Whitening activity Anti-wrinkle activity 

References

  1. 1.
    Kwak CS, Yang J (2016) Prevention effect of Prunus persica flos extract from reactive oxygen species generation and matrix metalloproteinases production induced by UVB irradiation in human skin cells. Asian J Beauty Cosmetol 14:179–190CrossRefGoogle Scholar
  2. 2.
    Gilchrest BA (1990) Skin aging and photoaging. Dermatol Nurs 2:79–82Google Scholar
  3. 3.
    Baumann L (2007) Skin ageing and its treatment. J Pathol 211:241–251CrossRefGoogle Scholar
  4. 4.
    Kim JO, Lee CW, Kim EK, Lee SJ, Park NH, Kim HS, Kim HK, Char KH, Jang YP, Kim JW (2011) Inhibition effect of Gynura procumbens extract on UV-B-induced matrix-metalloproteinase expression in human dermal fibroblasts. J Ethnopharmacol 137:427–433CrossRefGoogle Scholar
  5. 5.
    Chiang HM, Chen HC, Lin TJ, Shih IC, Wen KC (2012) Michelia alba extract attenuates UVB-induced expression of matrix metalloproteinases via MAP kinase pathway in human dermal fibroblasts. Food Chem Toxicol 50:4260–4269CrossRefGoogle Scholar
  6. 6.
    Kim DH, Park TS, Son JH (2015) Anti-wrinkle activities verification of Buplerum falcatum extracts on CCD-986sk. J Appl Biol Chem 58:183–187CrossRefGoogle Scholar
  7. 7.
    Kim MJ, Kim JY, Jung TK, Choi SW, Yoon KS (2006) Skin anti-aging effect of Forsythia viridissima L. extract. Korean J Biotechnol Bioeng 21:444–450Google Scholar
  8. 8.
    Park HJ, Ock SM, Kim HJ, Park HJ, Lee YB, Choi JM, Cho CS, Lee JY, Cho BK, Cho DH (2010) Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts. Exp Dermatol 19:258–264CrossRefGoogle Scholar
  9. 9.
    Cho JH, Kim HJ, Kim YB (2003) The study on depigmentation effects of salt, acetum, sesami semen nigrum. J Korean Med Ophthalmol Otolaryngol Dermatol 16:79–95Google Scholar
  10. 10.
    Gilchrest BA, Eller MS (1999) DNA photodamage stimulates melanogenesis and other photoprotective responses. J Investig Dermatol Symp Proc 4:35–40CrossRefGoogle Scholar
  11. 11.
    Chung AK (2003) Phenolic constituents from Tetragonia tetragonoides. Sungkyunkwan University, Seoul, pp 18–19Google Scholar
  12. 12.
    Nile SH, Ko EY, Kim DH, Keum YS (2016) Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity. Rev Bras Farmacogn 26:50–55CrossRefGoogle Scholar
  13. 13.
    Ogiwara T, Satoh K, Kadoma Y, Murakami Y, Unten S, Atsumi T, Sakagami H, Fujisawa S (2002) Radical scavenging activity and cytotoxicity of ferulic acid. Anticancer Res 22:2711–2717PubMedPubMedCentralGoogle Scholar
  14. 14.
    Kanski J, Aksenova M, Stoyanova A, Butterfield DA (2002) Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J Nutr Biochem 13:273–281CrossRefGoogle Scholar
  15. 15.
    Saija A, Tomaino A, Cascio RL, Trombetta D, Proteggente A, De Pasquale A, Uccella N, Bonina F (1999) Ferulic and caffeic acids as potential protective agents against photooxidative skin damage. J Sci Food Agric 79:476–480CrossRefGoogle Scholar
  16. 16.
    Balasubashini MS, Rukkumani R, Menon VP (2003) Protective effects of ferulic acid on hyperlipidemic diabetic rats. Acta Diabetol 40:118–122CrossRefGoogle Scholar
  17. 17.
    Mere PDBDL, Wilson MA, Rosser MJ (1973) The kinetics and mechanisms of additions to olefinic substances. Part XI. Stereochemistry of addition of chlorine acetate and of chlorine to some unsaturated compounds. J Chem Soc Perkin Trans 2(15):1480–1490CrossRefGoogle Scholar
  18. 18.
    Kim KS, Song JY, Lee IR (1999) Protective effects of the phenolic compounds from the leaves of Hedera rhombea on hepatic injury. Yakhak Hoeji 43:516–525Google Scholar
  19. 19.
    Gentry EJ, Jampani HB, Morton MD, Velde DV, Telikepalli H, Mitscher LA (1998) Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, β-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. J Nat Prod 61:1187–1193CrossRefGoogle Scholar
  20. 20.
    Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schutz A, Kovacic B, Friedrich K (2007) Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 9:279–291CrossRefGoogle Scholar
  21. 21.
    Gross J, Lapiere CM (1962) Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci 48:1014–1022CrossRefGoogle Scholar
  22. 22.
    Abdel-Malek Z, Swope VB, Suzuki I, Akcali C, Harriger MD, Boyce ST, Hearing VJ (1995) Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 92:1789–1793CrossRefGoogle Scholar
  23. 23.
    Lin CB, Babiarz L, Liebel F, Price ER, Kizoulis M, Gendimenico GJ, Seiberg M (2002) Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation. J Investig Dermatol 119:1330–1340CrossRefGoogle Scholar
  24. 24.
    Kobayashi T, Imokawa G, Bennett DC, Hearing VJ (1998) Tyrosinase stabilization by Tyrp1 (the brown Locus Protein). J Biol Chem 273:31801–31805CrossRefGoogle Scholar
  25. 25.
    Friedman PS, Wren F, Buffey J, Macnele S (1990) α-MSH causes a small rise in cAMP but has no effect on basal or ultra violet-stimulated melanogenesis in human melanocytes. Br J Dermatol 123:145–151CrossRefGoogle Scholar
  26. 26.
    Bentley NJ, Eisen T, Goding CR (1994) Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol Cell Biol 14:7996–8006CrossRefGoogle Scholar
  27. 27.
    Yasumoto K, Yokoyama K, Takahashi K, Tomita Y, Shibahara S (1997) Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes. J Biol Chem 272:503–509CrossRefGoogle Scholar
  28. 28.
    Hong YF, Lee HY, Jung BJ, Jang SJ, Chung DK, Kim HG (2015) Lipoteichoic acid isolated from Lactobacillus plantarum down-regulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation. Mol Immunol 67:248–255CrossRefGoogle Scholar
  29. 29.
    Wang Y, Johnson AR, Ye QZ, Dyer RD (1999) Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. J Biol Chem 274:33043–33049CrossRefGoogle Scholar
  30. 30.
    Kang TH, Park HM, Kim YB, Kim H, Kim N, Do JH, Kang C, Cho Y, Kim SY (2009) Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol 123:446–451CrossRefGoogle Scholar
  31. 31.
    Seo JE, Kim S, Shin MH, Kim MS, Eun HC, Park CH, Chung JH (2010) Ultraviolet irradiation induces thrombospondin-1 which attenuates type I procollagen downregulation in human dermal fibroblasts. J Dermatol Sci 59:16–24CrossRefGoogle Scholar
  32. 32.
    Yoo JM, Kang YJ, Pyo HB, Choung ES, Park SY, Choi JH, Han GJ, Lee CH, Kim TJ (2010) Anti-wrinkle effects of Korean rice wine cake on human fibroblast. J Life Sci 20:1838–1843CrossRefGoogle Scholar
  33. 33.
    Zhi-Hao S, Nian-Guang L, Qian-Ping S, Hao-Tang Yu-Ping T, Wei-Li Lian-Yin, Jian-Ping Y, Jin-Ao D (2013) Design, synthesis and biological evaluation of ferulic acid amides as selective matrix metalloproteinase inhibitors. Med Chem 9:947–954CrossRefGoogle Scholar
  34. 34.
    Thanyawan P, Tasanee O, Uraiwan P (2012) Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells. Photochem Photobiol 88:961–968CrossRefGoogle Scholar
  35. 35.
    Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang SW, Voorhees JJ (1997) Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 337:1419–1429CrossRefGoogle Scholar
  36. 36.
    Shephard P, Martin G, Smola-Hess S, Brunner G, Krieg T, Smola H (2004) Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-β and interleukin-1. Am J Pathol 164:2055–2066CrossRefGoogle Scholar
  37. 37.
    Rittie L, Fisher GJ (2002) UV-light-induced signal cascades and skin aging. Ageing Res Rev 1:705–720CrossRefGoogle Scholar

Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  • Hye-Jin Park
    • 1
  • Jun-Hyo Cho
    • 1
  • Shin-Hyub Hong
    • 1
  • Dong-Hee Kim
    • 2
  • Hee-Young Jung
    • 3
  • In-Kyu Kang
    • 4
  • Young-Je Cho
    • 1
    Email author
  1. 1.School of Food Science and Biotechnology/Institute of Agricultural Science and TechnologyKyungpook National UniversityDaeguRepublic of Korea
  2. 2.Applide Product Development TeamNational Development Institute of Korean MedicineGyeongsanRepublic of Korea
  3. 3.School of Applied BiosciencesKyungpook National UniversityDaeguRepublic of Korea
  4. 4.Department of Horticultural ScienceKyungpook National UniversityDaeguRepublic of Korea

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