Journal of Natural Medicines

, Volume 71, Issue 4, pp 765–769 | Cite as

Ceylonins G–I: spongian diterpenes from the marine sponge Spongia ceylonensis

  • Ahmed H. El-Desoky
  • Hikaru Kato
  • Sachiko Tsukamoto
Note

Abstract

Three new spongian diterpenes, ceylonins G–I (13), were isolated from the marine sponge Spongia ceylonensis collected in Indonesia, together with five known spongian diterpenes (48). Only 4 inhibited USP7 with an IC50 value of 8.2 μM.

Keywords

Marine sponge Spongia ceylonensis Spongian diterpene USP7 

Notes

Acknowledgements

We thank Prof. R. E. P. Mangindaan, Ms. F. Losung, and Ms. E. D. Angkouw of Sam Ratulangi University, Dr. H. Rotinsulu of Universitas Pembangunan, and Dr. H. Kobayashi of the University of Tokyo for collecting the sponges. This work was supported by Grants-in-Aid for Scientific Research (Nos. 18406002, 25293025, and 26305005 to S.T.) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2017

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesKumamoto UniversityKumamotoJapan
  2. 2.Division of Pharmaceutical Industries, Department of PharmacognosyNational Research CentreGizaEgypt

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