Journal of Natural Medicines

, Volume 70, Issue 4, pp 749–759 | Cite as

Gastrodin reversed the traumatic stress-induced depressed-like symptoms in rats

  • Bombi LeeEmail author
  • Bongjun Sur
  • Mijung Yeom
  • Insop Shim
  • Hyejung Lee
  • Dae-Hyun Hahm
Original Paper


Exposure to severe stress can lead to the development of neuropsychiatric disorders such as depression and post-traumatic stress disorder (PTSD) in at-risk individuals. Gastrodin (GAS), a primary constituent of an Oriental herbal medicine, has been shown to effectively treat various mood disorders. Thus, the present study aimed to determine whether GAS would ameliorate stress-associated depression-like behaviors in a rat model of single prolonged stress (SPS)-induced PTSD. Following the SPS procedure, rats received intraperitoneal administration of GAS (20, 50, or 100 mg/kg) once daily for 2 weeks. Subsequently, the rats performed the forced swimming test, and norepinephrine (NE) levels in the hippocampus were measured. Daily GAS (100 mg/kg) significantly reversed depression-like behaviors and restored SPS-induced increases in hippocampal NE concentrations as well as tyrosine hydroxylase expression in the locus coeruleus. Furthermore, the administration of GAS attenuated SPS-induced decreases in the hypothalamic expression of neuropeptide Y and the hippocampal mRNA expression of brain-derived neurotrophic factor. These findings indicate that GAS possesses antidepressant effects in the PTSD and may be an effective herbal preparation for the treatment of PTSD.


Post-traumatic stress disorder Single prolonged stress Depression Norepinephrine Gastrodin 



This research was supported by a Grant from the National Research Foundation of Korea funded by the Korean government (MEST) (2013R1A1A2063051).


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Bombi Lee
    • 1
    Email author
  • Bongjun Sur
    • 1
  • Mijung Yeom
    • 1
  • Insop Shim
    • 1
    • 2
  • Hyejung Lee
    • 1
  • Dae-Hyun Hahm
    • 1
    • 2
  1. 1.Acupuncture and Meridian Science Research Center, College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.The Graduate School of Basic Science of Korean Medicine, College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea

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