Journal of Natural Medicines

, Volume 70, Issue 3, pp 610–619 | Cite as

Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice

  • Hongxia Chen
  • Opeyemi J. Olatunji
  • Yifeng Zhou
Original Paper


The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ELC (50, 100, 200 and 400 mg/kg) before ethanol-induced ulcer increased the gastric mucus content, restored the superoxide dismutase and glutathione levels, reduced malondialdehyde levels and inhibited the activity of myeloperoxidase. Furthermore, ELC displayed its anti-secretory activity by decreasing the gastric juice and increased the gastric pH and reduced pro-inflammatory markers and caspase-3 tissue levels. These results suggest that L. chinense displays gastroprotective properties as a result of its antioxidant, anti-inflammatory, anti-secretory and anti-apoptotic effects.


Lycium chinense Cortex Lycii Antioxidant Ethanol Anti-inflammatory 



Thanks go to the Public Science and Technology Research Funds Projects of Ocean (no. 201505023) and the Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm (no. BM2014047) for the financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest related to this article.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Hongxia Chen
    • 1
    • 2
  • Opeyemi J. Olatunji
    • 2
  • Yifeng Zhou
    • 1
    • 3
  1. 1.Institute of Botany, Jiangsu Province and Chinese Academy of SciencesNanjing Botanical Garden Mem. Sun Yat-senNanjingChina
  2. 2.School of PharmacyJiangsu UniversityZhenjiangChina
  3. 3.Dongtai Institute of Tidal FlatNanjing Branch of Chinese Academy of SciencesDongtaiChina

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