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Journal of Natural Medicines

, Volume 69, Issue 3, pp 421–426 | Cite as

Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells

  • Kan’ichiro Ishiuchi
  • Yasuhiro Kosuge
  • Hazuki Hamagami
  • Mayu Ozaki
  • Kumiko Ishige
  • Yoshihisa Ito
  • Susumu Kitanaka
Note

Abstract

Effususol A (1), a new 9,10-dihydrophenanthrene, has been isolated from the medullae of Juncus effusus along with ten known compounds, effusol (2), dehydroeffusol (3), juncusol (4), dehydrojuncusol (5), juncuenin B (6), dehydrojuncuenin B (7), juncuenin D (8), luteolin (9), luteolin 5-methyl ether (10), and 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (11). The structure of 1 was elucidated on the basis of spectroscopic data. 2, 4, 6, 7, and 8 have induced caspase-3-mediated cytotoxicity in HT22 cells.

Keywords

Juncaceae Juncus effusus 9,10-Dihydrophenanthrene HT22 cells Cytotoxicity Caspase-3 

Notes

Acknowledgments

The authors thank Dr. K. Metori, Analytical Center, School of Pharmacy, Nihon University, for measurements of ESITOFMS. This work was supported by Grant-in-Aid for Scientific Research C (to S.K.).

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2015

Authors and Affiliations

  • Kan’ichiro Ishiuchi
    • 1
  • Yasuhiro Kosuge
    • 2
  • Hazuki Hamagami
    • 1
  • Mayu Ozaki
    • 1
  • Kumiko Ishige
    • 2
  • Yoshihisa Ito
    • 2
  • Susumu Kitanaka
    • 1
  1. 1.School of PharmacyNihon UniversityFunabashiJapan
  2. 2.Laboratory of Pharmacology, School of PharmacyNihon UniversityFunabashiJapan

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