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Journal of Natural Medicines

, Volume 67, Issue 2, pp 421–423 | Cite as

Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids

  • Shoji Maehara
  • Partomuan Simanjuntak
  • Yoshihide Maetani
  • Chinami Kitamura
  • Kazuyoshi Ohashi
  • Hirotaka Shibuya
Note

Abstract

We have investigated the ability of endophytic filamentous fungi associated with Cinchona ledgeriana (Rubiaceae) to produce Cinchona alkaloids on potato dextrose agar medium and in a synthetic liquid medium. It was found that all twenty-one endophytic fungi produce Cinchona alkaloids, despite their genetic differences.

Keywords

Endophytic filamentous fungus Cinchona alkaloid Cinchona ledgeriana Bioproduction Quinine 

Notes

Acknowledgments

This work was supported by a Strategic Support Project for Research Infrastructure Formation for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

References

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2012

Authors and Affiliations

  • Shoji Maehara
    • 1
  • Partomuan Simanjuntak
    • 2
  • Yoshihide Maetani
    • 1
  • Chinami Kitamura
    • 1
  • Kazuyoshi Ohashi
    • 1
  • Hirotaka Shibuya
    • 1
  1. 1.Faculty of Pharmacy and Pharmaceutical SciencesFukuyama UniversityFukuyamaJapan
  2. 2.Research Center for BiotechnologyIndonesian Institute of SciencesBogorIndonesia

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