Journal of Natural Medicines

, Volume 65, Issue 3, pp 662–669

Anti-HIV activity of Indian medicinal plants

  • Sudeep Sabde
  • Hardik S. Bodiwala
  • Aniket Karmase
  • Preeti J. Deshpande
  • Amandeep Kaur
  • Nafees Ahmed
  • Siddheshwar K. Chauthe
  • Keyur G. Brahmbhatt
  • Rasika U. Phadke
  • Debashis Mitra
  • Kamlesh Kumar Bhutani
  • Inder Pal Singh
Natural Resource Letter

DOI: 10.1007/s11418-011-0513-2

Cite this article as:
Sabde, S., Bodiwala, H.S., Karmase, A. et al. J Nat Med (2011) 65: 662. doi:10.1007/s11418-011-0513-2

Abstract

Acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. There is an urgent need for new, safe, and cheap anti-HIV agents. Traditional medicinal plants are a valuable source of novel anti-HIV agents and may offer alternatives to expensive medicines in future. Various medicinal plants or plant-derived natural products have shown strong anti-HIV activity and are under various stages of clinical development in different parts of the world. The present study was directed towards assessment of anti-HIV activity of various extracts prepared from Indian medicinal plants. The plants were chosen on the basis of similarity of chemical constituents with reported anti-HIV compounds or on the basis of their traditional usage as immunomodulators. Different extracts were prepared by Soxhlet extraction and liquid–liquid partitioning. Ninety-two extracts were prepared from 23 plants. Anti-HIV activity was measured in a human CD4+ T-cell line, CEM-GFP cells infected with HIV-1NL4.3. Nine extracts of 8 different plants significantly reduced viral production in CEM-GFP cells infected with HIV-1NL4.3. Aegle marmelos, Argemone mexicana, Asparagus racemosus, Coleus forskohlii, and Rubia cordifolia demonstrated promising anti-HIV potential and were investigated for their active principles.

Keywords

Anti-HIV AIDS Reverse transcriptase inhibitor Plant extracts Medicinal plants 

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2011

Authors and Affiliations

  • Sudeep Sabde
    • 1
  • Hardik S. Bodiwala
    • 2
  • Aniket Karmase
    • 2
  • Preeti J. Deshpande
    • 2
  • Amandeep Kaur
    • 2
  • Nafees Ahmed
    • 2
  • Siddheshwar K. Chauthe
    • 2
  • Keyur G. Brahmbhatt
    • 2
  • Rasika U. Phadke
    • 2
  • Debashis Mitra
    • 1
  • Kamlesh Kumar Bhutani
    • 2
  • Inder Pal Singh
    • 2
  1. 1.National Center for Cell Sciences (NCCS)PuneIndia
  2. 2.Department of Natural ProductsNational Institute of Pharmaceutical Education and Research (NIPER)PunjabIndia

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