Journal of Natural Medicines

, Volume 65, Issue 2, pp 391–394 | Cite as

Laevigatbenzoate from Croton laevigatus Vahl.

  • Guo-An Zou
  • Hong-Wu Zhang
  • Haji Akber Aisa
  • Jun-Shan Yang
  • Chao-Zhong Peng
  • Zhong-Mei Zou


A new trans-clerodane diterpenoid, laevigatbenzoate (1), was isolated from the leaves of Croton laevigatus Vahl. Its structure was established on the basis of spectroscopic analysis, and the absolute configuration was determined by application of the CD excitation chirality method. This compound showed weak cytotoxicity against HeLa cells, with an IC50 value of 45.4 μM.


Croton laevigatus Vahl. Euphorbiaceae Diterpenoid Laevigatbenzoate Cytotoxicity 



We gratefully acknowledge financial support from the Major Project of Chinese National Programs for Severe Infectious Diseases (2008ZX10003-006), National Natural Science Foundation of China (Grant No. 30900124), and the National S&T Major Special Project on Major New Drug Innovation (2009ZX09301-003). We also thank the staff of the Analytical Center, Beijing Institute of Microchemistry, China, for the measurements of NMR and mass spectra.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2011

Authors and Affiliations

  • Guo-An Zou
    • 1
    • 2
  • Hong-Wu Zhang
    • 1
  • Haji Akber Aisa
    • 2
  • Jun-Shan Yang
    • 1
  • Chao-Zhong Peng
    • 1
  • Zhong-Mei Zou
    • 1
  1. 1.Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingPeople’s Republic of China
  2. 2.Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesÜrümqiPeople’s Republic of China

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