Journal of Natural Medicines

, Volume 64, Issue 3, pp 365–369

Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

  • Ibrahim Jantan
  • Yusyila H. Mohd Yasin
  • Shajarahtunnur Jamil
  • Hasnah Sirat
  • Norazah Basar
Note

Abstract

Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC50 value of 100.9 μM. It also showed strong inhibition against ADP-induced aggregation, with an IC50 value of 57.1 μM. Isobavachalcone, 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC50 values ranging from 55.3 to 192.0 μM, but did not show such effect against other inducers.

Keywords

Artocarpus species Antiplatelet aggregation Human whole blood Cycloheterophyllin 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone Arachidonic acid 

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2010

Authors and Affiliations

  • Ibrahim Jantan
    • 1
  • Yusyila H. Mohd Yasin
    • 1
  • Shajarahtunnur Jamil
    • 2
  • Hasnah Sirat
    • 2
  • Norazah Basar
    • 2
  1. 1.Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia
  2. 2.Department of Chemistry, Faculty of ScienceUniversiti Teknologi MalaysiaSkudaiMalaysia

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