Journal of Natural Medicines

, Volume 64, Issue 2, pp 187–190 | Cite as

Free radical scavengers from the aerial parts of Euphorbia petiolata

  • Hossein Nazemiyeh
  • Elham Mohajjel Kazemi
  • Khadijeh Zare
  • Malakeh Jodari
  • Lutfun Nahar
  • Satyajit Dey Sarker


Reversed-phase preparative high-performance liquid chromatography (HPLC) of the methanol extract of the aerial parts of Euphorbia petiolata Banks & Soland, an endemic Iranian medicinal plant, yielded ten free radical scavengers including eight flavonoid glycosides myricetin 3-O-glucoside (1), kaempferol 3-O-(2-O-galloyl)-glucoside (2), myricetin 3-O-rhamnoside (3), quercetin 3-O-glucoside (4), kaempferol 3-O-glucoside (5), quercetin 3-O-rhamnoside (6), kaempferol 3-O-rhamnoside (7), and quercetin 3-O-rutinoside (10), a coumarin esculetin (8) and a phenylpropanoid 2-hydroxydihydrocinnamic acid (9). The structures of these compounds were elucidated conclusively by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. The free radical scavenging properties of these compounds were assessed by the 2,2-diphenyl-1-picrylhydrazyl assay.


Euphorbia petiolata Euphorbiaceae Phenolic Flavonoid Antioxidant DPPH 



We thank the Talent Students’ Department, University of Tabriz, for financial support.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2009

Authors and Affiliations

  • Hossein Nazemiyeh
    • 1
  • Elham Mohajjel Kazemi
    • 2
  • Khadijeh Zare
    • 2
  • Malakeh Jodari
    • 1
  • Lutfun Nahar
    • 3
  • Satyajit Dey Sarker
    • 4
  1. 1.Research Center for Pharmaceutical Nanotechnology, Faculty of PharmacyTabriz University of Medical SciencesTabrizIran
  2. 2.Talent Students’ CenterUniversity of TabrizTabrizIran
  3. 3.Drug Discovery and Design Research Division, Department of Pharmacy, School of Applied SciencesUniversity of WolverhamptonWolverhamptonUK
  4. 4.Department of Pharmacy, School of Applied SciencesUniversity of WolverhamptonWolverhamptonUK

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