Hydroxyespintanol and schefflerichalcone: two new compounds from Uvaria scheffleri

  • Momoyo Ichimaru
  • Noriyoshi Nakatani
  • Masataka Moriyasu
  • Yumi Nishiyama
  • Atsushi Kato
  • Simon G. Mathenge
  • Francis D. Juma
  • Patrick B. ChaloMutiso
Note
First Online:
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Accepted:

Abstract

A chemical investigation of the petroleum ether extract and chloroform extract of the root of Uvaria scheffleri Diels (Annonaceae) led to the isolation of two new compounds, named hydroxyespintanol (1) and schefflerichalcone (2), together with eight known compounds (3–10). The structural elucidation of compounds 1 and 2 by spectroscopic studies is described. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was studied. Among these, 2′-hydroxy-3′,4′,6′-trimethoxychalcone (5) exhibited cytotoxicity (IC50 12 µM), and espintanol (3), which was the main ingredient, also showed some cytotoxicity (IC50 44 µM).

Keywords

Uvaria scheffleri Hydroxyespintanol Schefflerichalcone Cytotoxicity against HL-60 
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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2009

Authors and Affiliations

  • Momoyo Ichimaru
    • 1
  • Noriyoshi Nakatani
    • 1
  • Masataka Moriyasu
    • 1
  • Yumi Nishiyama
    • 1
  • Atsushi Kato
    • 1
  • Simon G. Mathenge
    • 2
  • Francis D. Juma
    • 3
  • Patrick B. ChaloMutiso
    • 2
  1. 1.Department of Natural Medicinal ChemistryKobe Pharmaceutical UniversityKobeJapan
  2. 2.Department of Natural Medicinal ChemistryUniversity of NairobiNairobiKenya
  3. 3.Department of MedicineUniversity of NairobiNairobiKenya

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