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Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii

  • Rene Angelo Macahig
  • Liva Harinantenaina
  • Katsuyoshi Matsunami
  • Hideaki Otsuka
  • Yoshio Takeda
  • Takakazu Shinzato
Original Paper

Abstract

Phytochemical investigation of the dried leaves of Fraxinus griffithii collected in Okinawa has led to the isolation of three new secoiridoid glucosides, griffithosides A–C (13), and one new iridoid glucoside, 7-epi-7-O-(E)-caffeoylloganic acid (4), along with eight known secoiridoid glucosides (512). The structures of these compounds were elucidated by means of NMR, MS, and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity. Among them, compounds 3, 4, and 7 exhibited substantial radical-scavenging activity.

Keywords

Fraxinus griffithii Oleaceae Secoiridoid glucoside Iridoid glucoside Radical-scavenging activity 

Notes

Acknowledgments

The authors are grateful for access to the superconducting NMR instrument and the HR-ESI-MS at the Analytical Center of Molecular Medicine and the Analysis Center of Life Science, respectively, of the Graduate School of Biomedical Sciences, Hiroshima University. One (RAM) of the authors expresses his gratitude to the Ministry of Education, Sports, Culture and Technology of Japan for the academic scholarship.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2009

Authors and Affiliations

  • Rene Angelo Macahig
    • 1
  • Liva Harinantenaina
    • 1
  • Katsuyoshi Matsunami
    • 1
  • Hideaki Otsuka
    • 1
  • Yoshio Takeda
    • 2
  • Takakazu Shinzato
    • 3
  1. 1.Department of Pharmacognosy, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Faculty of PharmacyYasuda Women’s UniversityHiroshimaJapan
  3. 3.Subtropical Field Science Center, Faculty of AgricultureUniversity of the RyukyusNakagami-gunJapan

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