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Journal of Natural Medicines

, Volume 62, Issue 3, pp 308–313 | Cite as

Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum

  • Yoshiyuki KimuraEmail author
  • Maho Sumiyoshi
  • Masahiko Taniguchi
  • Kimiye Baba
Original Paper

Abstract

In a series of studies on the search for new antitumor and antimetastatic substances from the natural medicinal plants of the Umbelliferae family, we previously reported that chalcone derivatives isolated from Angelica keisekei roots have antitumor and antimetastatic activities. In the present study, we examined the effects of a chromone glucoside cnidimoside A isolated from Cnidium japonicum whole plants on tumor growth and tumor metastasis in colon 26-bearing mice. Cnidimoside A (50 mg/kg, twice daily) significantly inhibited tumor growth and final tumor weight compared to the growth in vehicle-treated colon 26-bearing mice (control). Furthermore, the number of mice with abdominal invasion of tumors was also reduced by orally administered cnidimoside A (50 mg/kg, twice daily). In this study, the CD8+ T Cell- and interferon (IFN)-γ-positive cell numbers in the small intestine in the colon 26-bearing mice were significantly reduced compared with those in the normal mice, but the natural killer (NK)-positive cell number did not differ significantly between the normal and colon 26-bearing mice. The CD8+ T-, NK and IFN-γ-positive cell numbers in the small intestine were significantly increased by orally administered cnidimoside A (50 mg/kg, twice daily) compared to those in vehicle-treated colon 26-bearing mice. In conclusion, it seems likely that the antitumor and antimetastatic actions of cnidimoside A may be partly associated with the stimulation of immune response in the small intestine.

Keywords

Cnidimoside A Antitumor action Colon 26 Immune function Small intestine 

Notes

Acknowledgments

This work was supported by grant-in-aid for Scientific Research on Priority Area (No. 17035059 and 18032504; A representative: Yoshiyuki Kimura) and Scientific Research (C) (No. 18590654; A representative: Yoshiyuki Kimura) from The Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2008

Authors and Affiliations

  • Yoshiyuki Kimura
    • 1
    Email author
  • Maho Sumiyoshi
    • 2
  • Masahiko Taniguchi
    • 3
  • Kimiye Baba
    • 3
  1. 1.Division of Biochemical Pharmacology, Department of Basic Medical ResearchEhime University Graduate School of MedicineEhimeJapan
  2. 2.Division of Functional Histology, Department of Functional BiomedicineEhime University Graduate School of MedicineEhimeJapan
  3. 3.Department of PharmacognosyOsaka University of Pharmaceutical SciencesTakatsuki, OsakaJapan

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