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Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats

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Abstract

Plants with antidiabetic activities provide important sources for the development of new drugs in the treatment of diabetes mellitus. In the present study, we investigated possible antihyperglycemic and antioxidative activities of the aerial part of the Matricaria chamomilla L. ethanolic extract (MCE) in streptozotocin (STZ; 70 mg/kg, i.p.)-induced diabetic rats. The following groups were assigned; sham (did not receive any substance), STZ + distilled water (control), STZ + 5 mg/kg glibenclamide, STZ + 20 mg/kg MCE, STZ + 50 mg/kg MCE, STZ + 100 mg/kg MCE. Diabetic rats were treated for 14 days by gavage. Postprandial blood glucose levels, malondialdehyde, reduced glutathione (GSH), nitrate, nitrite, ascorbic acid, retinol, β-carotene, superoxide dismutase, and catalase levels were measured, and immunohistochemical studies were performed in all of the groups. The obtained data showed that STZ resulted in oxidative stress and affected the antioxidant status. Treatment with different doses of MCE significantly reduced postprandial hyperglycemia and oxidative stress, and augmented the antioxidant system. In histological investigations, MCE treatment protected the majority of the pancreatic islet cells, with respect to the control group. As a result, MCE exhibited significant antihyperglycemic effect and protected β-cells in STZ-diabetic rats, in a dose-dependent manner, and diminished the hyperglycemia-related oxidative stress.

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Acknowledgments

This study was supported by a grant from the Afyon Kocatepe University research fund (06.FENED.07). The authors thank Prof. Dr. Abdullah Çağlar, Faculty of Food Engineering, Afyon Kocatepe University, for the helpful suggestions to this paper.

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Authors and Affiliations

  1. Department of Chemistry (Biochemistry Division), Faculty of Sciences and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Mustafa Cemek & Sadık Kağa

  2. Department of Histology and Embriyology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey

    Nejdet Şimşek

  3. Department of Pharmacology, Faculty of Medicine, Afyon Kocatepe University, Ali Cetinkaya Kampusu, Izmir yolu 9. km, 03200, Afyonkarahisar, Turkey

    Mehmet Emin Büyükokuroğlu

  4. Department of Biology, Faculty of Sciences and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Muhsin Konuk

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  1. Mustafa Cemek
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  2. Sadık Kağa
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  3. Nejdet Şimşek
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  4. Mehmet Emin Büyükokuroğlu
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Correspondence to Mehmet Emin Büyükokuroğlu.

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Cemek, M., Kağa, S., Şimşek, N. et al. Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats. J Nat Med 62, 284–293 (2008). https://doi.org/10.1007/s11418-008-0228-1

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  • DOI: https://doi.org/10.1007/s11418-008-0228-1

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