Potential anthelmintic: d-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditis elegans
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No anthelmintic sugars have yet been identified. Eight ketohexose stereoisomers (d- and l-forms of psicose, fructose, tagatose and sorbose), along with d-galactose and d-glucose, were examined for potency against L1 stage Caenorhabditis elegans fed Escherichia coli. Of the sugars, d-psicose specifically inhibited the motility, growth and reproductive maturity of the L1 stage. d-Psicose probably interferes with the nematode nutrition. The present results suggest that d-psicose, one of the rare sugars, is a potential anthelmintic.
Keywordsd-Psicose Caenorhabditis elegans Inhibitory effect Motility Developmemt Anthelmintic
The authors wish to thank Prof. Kazuhiro Fukada of Kagawa University for valuable discussions on this topic. This research was supported in part by a grant from the Glyco-Biocluster Plan Based on Rare Sugars of the Ministry of Education, Science, Sports and Culture of Japan.
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