Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells
A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (−)-ampelopsin A (2), (−)-α-viniferin (3), ampelopsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.
KeywordsDiptoindonesin F Oligostilbenoid Shorea gibbosa Dipterocarpaceae Cytotoxicity P-388 cells
We thank Dr. H. Karasawa and Dr. A. Kusai from JEOL, Japan, for mass spectra measurements. We also thank the Herbarium Bogoriense, Bogor, Indonesia, for identification of the plant specimen.
- 2.Seo EK, Douglas KA (2000) Bioactive constituents of the family Dipterocarpaceae. In: Atta-ur-Rahman (ed) Studies in natural products chemistry. vol 23 (Bioactive Natural Products (Part D)), Elsevier, pp 531–561Google Scholar
- 3.Cichewicz RH, Kouzi SA (2002) Resveratrol oligomers: structure, chemistry, and biological activity. In: Atta-ur-Rahman (ed) Studies in natural products chemistry. vol 26 (Bioactive Natural Products, (Part G)), Elsevier, pp 507–579Google Scholar
- 6.Sahidin, Hakim EH, Juliawaty LD, Syah YM, Din LB, Ghisalberti EL, Latip J, Said IM, Achmad SA (2005) Cytotoxic properties of oligostilbenoids from the tree bark of Hopea dryobalanoides. Z Naturforsch 60c:723–727Google Scholar