Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells
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A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (−)-ampelopsin A (2), (−)-α-viniferin (3), ampelopsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.
KeywordsDiptoindonesin F Oligostilbenoid Shorea gibbosa Dipterocarpaceae Cytotoxicity P-388 cells
We thank Dr. H. Karasawa and Dr. A. Kusai from JEOL, Japan, for mass spectra measurements. We also thank the Herbarium Bogoriense, Bogor, Indonesia, for identification of the plant specimen.
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