Journal of Natural Medicines

, Volume 61, Issue 3, pp 323–328 | Cite as

Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals

  • G. Amresh
  • Hussain Zeashan
  • Ram Ji Gupta
  • Ravi Kant
  • Chandana Venkateswara Rao
  • Paras Nath Singh


Ethanolic extract of Cissampelos pareira (L.) Hirsuta (Menispermaceae) roots have been examined in various acute and chronic ulcers in validated experimental models in rats. C. pareira extract of 25–100 mg/kg administered orally, twice daily for 5 days showed a dose-dependent, ulcer-protective effect. The extract demonstrated significant protection against 100% ethanol- (P < 0.05), aspirin- (P < 0.001), cold-restraint stress- (P < 0.01) and pylorus ligation- (P < 0.001) induced acute gastric ulcers in rats. A flavonoid Quercetin, isolated from C. pareira, showed significant antiulcer property (P < 0.05 to P < 0.001) against gastric ulcers in different acute models. In chronic ulcers induced by 50% acetic acid, C. pareira significantly (P < 0.001) reduced the ulcer index with decreased perforations after 5- and 10-day treatment. C. pareira significantly enhanced the defense factors as total hexose and sialic acid while significantly reducing the ulcer index in the lipid peroxidase product malondialdehyde in ethanol-induced ulcers.


Antiulcer activity C. pareira Menispermaceae Quercetin 



This study was supported by grants from the Department of Science and Technology, Ministry of Science and Technology, New Delhi (GAP273225 and GAP273525). Authors are highly thankful to Director NBRI, Lucknow, for providing the necessary facilities.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2007

Authors and Affiliations

  • G. Amresh
    • 1
  • Hussain Zeashan
    • 1
  • Ram Ji Gupta
    • 1
  • Ravi Kant
    • 1
  • Chandana Venkateswara Rao
    • 1
  • Paras Nath Singh
    • 2
  1. 1.Pharmacognosy and Ethnopharmacology DivisionNational Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap MargLucknow India
  2. 2.Department of Pharmaceutics, Institute of TechnologyBanaras Hindu UniversityVaranasiIndia

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