Journal of Computer Science and Technology

, Volume 25, Issue 1, pp 154–168 | Cite as

Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity

Survey

Abstract

Modern molecular biology has always been a great source of inspiration for computational science. Half a century ago, the challenge from understanding macromolecular dynamics has led the way for computations to be part of the tool set to study molecular biology. Twenty-five years ago, the demand from genome science has inspired an entire generation of computer scientists with an interest in discrete mathematics to join the field that is now called bioinformatics. In this paper, we shall lay out a new mathematical theory for dynamics of biochemical reaction systems in a small volume (i.e., mesoscopic) in terms of a stochastic, discrete-state continuous-time formulation, called the chemical master equation (CME). Similar to the wavefunction in quantum mechanics, the dynamically changing probability landscape associated with the state space provides a fundamental characterization of the biochemical reaction system. The stochastic trajectories of the dynamics are best known through the simulations using the Gillespie algorithm. In contrast to the Metropolis algorithm, this Monte Carlo sampling technique does not follow a process with detailed balance. We shall show several examples how CMEs are used to model cellular biochemical systems. We shall also illustrate the computational challenges involved: multiscale phenomena, the interplay between stochasticity and nonlinearity, and how macroscopic determinism arises from mesoscopic dynamics. We point out recent advances in computing solutions to the CME, including exact solution of the steady state landscape and stochastic differential equations that offer alternatives to the Gilespie algorithm. We argue that the CME is an ideal system from which one can learn to understand “complex behavior” and complexity theory, and from which important biological insight can be gained.

Keywords

biochemical networks cellular signaling epigenetics master equation nonlinear reactions stochastic modeling 

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Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Department of BioengineeringUniversity of Illinois at ChicagoChicagoU.S.A.
  2. 2.Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghaiChina
  3. 3.Department of Applied MathematicsUniversity of WashingtonSeattleU.S.A.
  4. 4.Kavli Institute for Theoretical Physics ChinaChinese Academy of SciencesBeijingChina

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