Journal of Computer Science and Technology

, Volume 25, Issue 1, pp 124–130

Protein Interactome Analysis for Countering Pathogen Drug Resistance

Survey

DOI: 10.1007/s11390-010-9310-8

Cite this article as:
Wong, L. & Liu, G. J. Comput. Sci. Technol. (2010) 25: 124. doi:10.1007/s11390-010-9310-8

Abstract

Drug-resistant varieties of pathogens are now a recognized global threat. Insights into the routes for drug resistance in these pathogens are critical for developing more effective antibacterial drugs. A systems-level analysis of the genes, proteins, and interactions involved is an important step to gaining such insights. This paper discusses some of the computational challenges that must be surmounted to enable such an analysis; viz., unreliability of bacterial interactome maps, paucity of bacterial interactome maps, and identification of pathways to bacterial drug resistance.

Keywords

protein complexes protein interactomes drug resistance infectious diseases 

Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.School of ComputingNational University of SingaporeSingaporeSingapore

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