Journal of Computer Science and Technology

, Volume 25, Issue 1, pp 26–34

Challenges in Understanding Genome-Wide DNA Methylation


DOI: 10.1007/s11390-010-9302-8

Cite this article as:
Zhang, M.Q. & Smith, A.D. J. Comput. Sci. Technol. (2010) 25: 26. doi:10.1007/s11390-010-9302-8


DNA methylation is a chemical modification of the bases in genomes. This modification, most frequently found at CpG dinucleotides in eukaryotes, has been identified as having multiple critical functions in broad and diverse species of animals and plants, while mysteriously appears to be lacking from several other well-studied species. DNA methylation has well known and important roles in genome stability and defense, its pattern change highly correlates with gene regulation. Much evidence has linked abnormal DNA methylation to human diseases. Most prominently, aberrant DNA methylation is a common feature of cancer genomes. Elucidating the precise functions of DNA methylation therefore has great biomedical significance. Here we provide an update on large-scale experimental technologies for detecting DNA methylation on a genomic scale. We also discuss new prospect and challenges that computational biologist will face when analyzing DNA methylation data.


DNA methylation epigenome computational epigenomics 

Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Cold Spring Harbor LaboratoryNew YorkU.S.A.
  2. 2.Bioinformatics Division, TNLIST and MOE Key Lab of BioinformaticsTsinghua UniversityBeijingChina
  3. 3.Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesU.S.A.

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