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MALT-Lymphom

Mit einer Helicobacter-pylori-Eradikation heilbar?

Mucosa-associated lymphoid tissue lymphoma

Can it be cured by eradication of Helicobacter pylori?

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Zusammenfassung

Die Bedeutung der Helicobacter-pylori-Infektion für die Entstehung und Progression von MALT-Lymphomen des Magens steht außer Zweifel. Es war daher nur logisch, die Eradikationsbehandlung in das therapeutische Konzept der MALT-Lymphome zu integrieren. Aus vielen großen prospektiven Studien wissen wir heute, dass die erfolgreiche Keimeradikation in etwa 80% zu einer kompletten Remission gastraler MALT-Lymphome im lokalisierten Stadium I führt. Die Langzeitprognose der meisten Patienten mit Lymphomremission nach Helicobacter-pylori-Eradikation ist sehr gut, sodass heute von einer berechtigten Hoffnung auf Heilung ausgegangen werden kann.

Abstract

There is general concern about the significance of Helicobacter pylori infection for the development and progression of gastric MALT lymphoma. If any further evidence were needed for this association, it has been provided by experience with Helicobacter pylori eradication treatment. We know from many large prospective studies that successful eradication of the bacteria leads to a complete remission of localized (stage I) gastric MALT lymphoma in some 80% of cases. The long-term prognosis of most patients with complete regression of the lymphoma after eradication of Helicobacter pylori is excellent. We, therefore, think that this approach provides a genuine chance to be cured.

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Correspondence to Prof. Dr. W. Fischbach.

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Fischbach, W. MALT-Lymphom. Gastroenterologe 1, 279–283 (2006). https://doi.org/10.1007/s11377-006-0044-7

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Schlüsselwörter

  • MALT Lymphom
  • Helicobacter pylori
  • Eradikation
  • Lymphomregression
  • Heilung

Keywords

  • MALT lymphoma
  • Helicobacter pylori
  • Eradication
  • Lymphoma regression
  • Cure