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Sulforaphane - role in aging and neurodegeneration

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Abstract

In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables. SFN activates the antioxidant and anti-inflammatory responses by inducing Nrf2 pathway and inhibiting NF-κB. It also has an epigenetic effect by inhibiting HDAC and DNA methyltransferases and modifies mitochondrial dynamics. Moreover, SFN preserves proteome homeostasis (proteostasis) by activating the proteasome, which has been shown to lead to increased cellular lifespan and prevent neurodegeneration. In this review, we describe some of the molecular and physical characteristics of SFN, its mechanisms of action, and the effects that SFN treatment induces in order to discuss its relevance as a “miraculous” drug to prevent aging and neurodegeneration.

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Funding

This work was supported by CONACyT grant FON.INST/298/2016, as well as the “Red Temática de Investigación en Salud y Desarrollo Social” from CONACYT, Mexico. Santín-Márquez is a CONACyT scholarship holder. Research from NC lab is currently co-financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, (a) under the call RESEARCH – CREATE – INNOVATE (project code: T1EDK-00353 and T1EDK-01610) and (b) under the Action “Action for the Strategic Development on the Research and Technological Sector” (project STHENOS-b, MIS 5002398).

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  1. Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, 09340, Mexico City, Mexico

    Roberto Santín-Márquez, Adriana Alarcón-Aguilar, Norma Edith López-Diazguerrero & Mina Königsberg

  2. Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, 09340, Mexico City, Mexico

    Roberto Santín-Márquez

  3. National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece

    Niki Chondrogianni

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  1. Roberto Santín-Márquez
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  2. Adriana Alarcón-Aguilar
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  3. Norma Edith López-Diazguerrero
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  5. Mina Königsberg
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Correspondence to Mina Königsberg.

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Santín-Márquez, R., Alarcón-Aguilar, A., López-Diazguerrero, N.E. et al. Sulforaphane - role in aging and neurodegeneration. GeroScience 41, 655–670 (2019). https://doi.org/10.1007/s11357-019-00061-7

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