, 38:46 | Cite as

Joint effect of gene-physical activity and the interactions among CRP, TNF-α, and LTA polymorphisms on serum CRP, TNF-α levels, and handgrip strength in community-dwelling elders in Taiwan - TCHS-E

  • Chia-Ing Li
  • Tsai-Chung Li
  • Li-Na Liao
  • Chiu-Shong Liu
  • Chuan-Wei Yang
  • Chih-Hsueh Lin
  • Jen-Hao Hsiao
  • Nai-Hsin Meng
  • Wen-Yuan Lin
  • Fang-Yang WuEmail author
  • Cheng-Chieh LinEmail author


This study assesses interactions of tumor necrosis factor α (TNF-α) gene polymorphisms with C-reactive protein (CRP) or lymphotoxin α (LTA) gene on serum CRP and TNF-α levels and handgrip strength. Eleven single nucleotide polymorphisms (SNPs), including rs2794520, rs1205, rs1130864, rs1800947, and rs3093059 in CRP; rs1799964, rs1800629, and rs3093662 in TNF-α; and rs2239704, rs909253, and rs1041981 in LTA, were genotyped in 472 unrelated elders (mean age 73.8 years). Among elders with TNF-α rs1799964 AA genotype, adjusted mean difference for handgrip strength decreased by −2.60 (−4.82, −0.38) and −2.51 kg (−4.75, −0.28) for LTA rs909253 and rs1041981 in women and by −2.39 kg (−3.98, −0.81) for CRP rs3093059 in men. Among elders with TNF-α rs1799964 AA genotype, adjusted mean ratios for hs-CRP levels increased by 2.32 (1.38, 3.90) and 2.27 (1.35, 3.84) for both CRP rs909253 and rs1041981 in women. The A-A-C LTA haplotype was associated with TNF-α levels that were 1.55 times higher than those of the C-G-A haplotype (P = 0.005). The joint effects of SNPs (the rs1800947 or rs3093059 of CRP, rs1799964 or rs1800629 of TNF-α, and rs909253 or rs1041981 of LTA) and physical inactivity appeared to have greater magnitude of decreased handgrip strength than main effects of these SNPs and physical inactivity. Our data showed that significant interactions of TNF-αrs1799964 and LTA rs909253 were observed. Moreover, joint effects of these CRP, TNF-α, and LTA risk alleles with physical inactivity in elders were observed, suggesting that physical activity may modulate effects of genotypes on handgrip strength.


CRP TNF-α LTA SNP Joint effect Interaction Handgrip strength 



This study was supported by grants from the National Health Research Institutes of Taiwan (NHRI-EX98-9838PI), China Medical University Hospital (DMR-104-067), and the Taiwan Department of Health Clinical Trial and Research Center of Excellence (MOHW105-TDU-B-212-133019).

Compliance with ethical standards


The authors have no funding and conflicts of interest to disclose.


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Copyright information

© American Aging Association 2016

Authors and Affiliations

  • Chia-Ing Li
    • 1
  • Tsai-Chung Li
    • 3
    • 4
  • Li-Na Liao
    • 1
  • Chiu-Shong Liu
    • 1
    • 5
  • Chuan-Wei Yang
    • 2
    • 6
  • Chih-Hsueh Lin
    • 1
    • 5
  • Jen-Hao Hsiao
    • 7
  • Nai-Hsin Meng
    • 1
    • 8
  • Wen-Yuan Lin
    • 1
    • 5
  • Fang-Yang Wu
    • 9
    Email author
  • Cheng-Chieh Lin
    • 1
    • 5
    Email author
  1. 1.School of Medicine, College of MedicineChina Medical UniversityTaichungTaiwan
  2. 2.Department of Medical ResearchChina Medical University HospitalTaichungTaiwan
  3. 3.Graduate Institute of Biostatistics, College of Public HealthChina Medical UniversityTaichungTaiwan
  4. 4.Department of Healthcare Administration, College of Medical and Health SciencesAsia UniversityTaichungTaiwan
  5. 5.Department of Family MedicineChina Medical University HospitalTaichungTaiwan
  6. 6.Ph.D. Program for Aging, College of MedicineChina Medical UniversityTaichungTaiwan
  7. 7.Bioinformatics and Biostatistics Core, Center of Genomic MedicineNational Taiwan UniversityTaipeiTaiwan
  8. 8.Department of Physical Medicine and RehabilitationChina Medical University HospitalTaichungTaiwan
  9. 9.Department of Public Health, College of Public HealthChina Medical UniversityTaichungTaiwan

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