, 37:98 | Cite as

Improving healthspan via changes in gut microbiota and fermentation

  • Michael J. Keenan
  • Maria L. Marco
  • Donald K. Ingram
  • Roy J. MartinEmail author


Dietary resistant starch impact on intestinal microbiome and improving healthspan is the topic of this review. In the elderly population, dietary fiber intake is lower than recommended. Dietary resistant starch as a source of fiber produces a profound change in gut microbiota and fermentation in animal models of aging. Dietary resistant starch has the potential for improving healthspan in the elderly through multiple mechanisms as follows: (1) enhancing gut microbiota profile and production of short-chain fatty acids, (2) improving gut barrier function, (3) increasing gut peptides that are important in glucose homeostasis and lipid metabolism, and (4) mimicking many of the effects of caloric restriction including upregulation of genes involved in xenobiotic metabolism.


Resistant starch Gut microbiota Gut peptides Healthspan Prebiotic Gut health Short-chain fatty acids Butyrate Age-related anorexia Caloric restriction mimetic 


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Copyright information

© American Aging Association 2015

Authors and Affiliations

  1. 1.Louisiana State University Agricultural CenterBaton RougeUSA
  2. 2.Robert Mondavi Institute for Wine and Food ScienceDavisUSA
  3. 3.Pennington Biomedical Research CenterBaton RougeUSA
  4. 4.Western Human Nutrition Research CenterDavisUSA

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