, 36:9666 | Cite as

Diphenyl diselenide-supplemented diet and swimming exercise enhance novel object recognition memory in old rats

  • José L. Cechella
  • Marlon R. Leite
  • Alisson R. Rosario
  • Tuane B. Sampaio
  • Gilson Zeni


The benefits of exercise and the element selenium on mental health and cognitive performance are well documented. The purpose of the present study was to investigate whether the intake of a diet supplemented with diphenyl diselenide [(PhSe)2] and the swimming exercise could enhance memory in old Wistar rats. Male Wistar rats (24 months) were fed daily with standard diet chow or standard chow supplemented with 1 ppm of (PhSe)2 during 4 weeks. Animals were submitted to swimming training with a workload (3 % of body weight, 20 min/day for 4 weeks). After 4 weeks, the object recognition test (ORT) and the object location test (OLT) were performed. The results of this study demonstrated that intake of a supplemented diet with (PhSe)2 and swimming exercise was effective in improving short-term and long-term memory as well as spatial learning, increasing the hippocampal levels of phosphorylated cAMP-response element-binding protein (CREB) in old rats. This study also provided evidence that (PhSe)2-supplemented diet facilitated memory of old rats by modulating cAMP levels and stimulating CREB phosphorylation, without altering the levels of Akt.


Selenium Organoselenium Exercise Memory Age 



The financial support by UFSM, CAPES, FAPERGS/CNPq (PRONEX), and research grant FAPERGS no. 10/0711-6 is gratefully acknowledged. G.Z. is a recipient of CNPq fellowship.

Conflict of interest

The authors declare no conflict of interests in the present study.


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Copyright information

© American Aging Association 2014

Authors and Affiliations

  • José L. Cechella
    • 1
  • Marlon R. Leite
    • 1
  • Alisson R. Rosario
    • 1
  • Tuane B. Sampaio
    • 1
  • Gilson Zeni
    • 1
  1. 1.Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e ExatasUniversidade Federal de Santa MariaSanta MariaBrazil

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