Explosive type of moderate-resistance training induces functional, cardiovascular, and molecular adaptations in the elderly
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Current recommendations aimed at reducing neuromuscular and functional loss in aged muscle have identified muscle power as a key target for intervention trials, although little is known about the biological and cardiovascular systemic response in the elderly. This study investigated the effects of 12 weeks of low-frequency, moderate-intensity, explosive-type resistance training (EMRT) on muscle strength and power in old community-dwelling people (70–75 years), monitoring functional performance linked to daily living activities (ADL) and cardiovascular response, as well as biomarkers of muscle damage, cardiovascular risk, and cellular stress response. The present study provides the first evidence that EMRT was highly effective in achieving a significant enhancement in muscular strength and power as well as in functional performance without causing any detrimental modification in cardiovascular, inflammatory, and damage parameters. Moreover, trained elderly subjects showed an adaptive response at both systemic and cellular levels by modulation of antioxidant and stress-induced markers such as myeloperoxidase (MPO), heat shock protein 70 (Hsp70) and 27 (Hsp27), and thioredoxin reductase 1 (TrxR1).
KeywordsStrength training Elderly Hemodynamic parameters HSPs Thioredoxin system
This work was supported by grants from the University of Rome “Foro Italico” (Research 2009) to D. C. The Lazio Regional Municipality (Agreement CRUL-Lazio n. 12650/2010) supported the post-doc scholarship to ID.
Conflict of interest
Each author of this study further declares no relationships with the companies or manufacturers who will benefit from the results of the present study. The authors of this article declare no conflicts of interest.
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