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AGE

, Volume 36, Issue 1, pp 231–241 | Cite as

Normal values of regional and global myocardial wall motion in young and elderly individuals using navigator gated tissue phase mapping

  • Ion CodreanuEmail author
  • Tammy J. Pegg
  • Joseph B. Selvanayagam
  • Matthew D. Robson
  • Oliver J. Rider
  • Constantin A. Dasanu
  • Bernd A. Jung
  • David P. Taggart
  • Stephen J. Golding
  • Kieran Clarke
  • Cameron J. Holloway
Article

Abstract

The purpose of this study was to evaluate normal values for regional and global myocardial wall motion parameters in young and elderly individuals, as detected by navigator gated high temporal resolution tissue phase mapping. Radial, longitudinal and circumferential ventricular wall motion, as well as ventricular torsion and longitudinal strain rates, were assessed in two age groups of volunteers, 23 ± 3 (n = 14) and 66 ± 7 years old (n = 9), respectively. All subjects were healthy, non-smokers without known cardiac disease. An increased global left ventricular (LV) torsion rate (peak systolic torsion rate 20.6 ± 2.0 versus 14.5 ± 1.0°/s/cm, peak diastolic torsion rate −25.2 ± 1.8 versus −14.1 ± 1.3°/s/cm) and a decrease in longitudinal LV motion (peak systolic values at mid-ventricle 5.9 ± 0.5 versus 8.5 ± 0.8 cm/s, peak diastolic values −10.7 ± 0.7 versus −15.2 ± 0.9 cm/s) in the older age group were the most prominent findings. Lower peak diastolic radial velocities with a longer time-to-peak values, most pronounced at the apex, are consistent with reduced diastolic function with ageing. Lower peak clockwise and counter-clockwise velocities at all LV levels revealed limitations in resting LV rotational motions in the older group. Significant changes in the undulating pattern of the rotational motions of the left ventricle were also observed. The results demonstrate distinct changes in regional and global myocardial wall motion in elderly individuals. Increased LV torsion rate and reduced LV longitudinal motion were particularly prominent in the older group. These parameters may have a role in the assessment of global LV contractility and help differentiate age-related changes from cardiac disease.

Keywords

Ventricular wall motion Cardiac magnetic resonance Phase contrast velocity mapping 

Notes

Acknowledgments

This research was funded by the British Heart Foundation and was supported by the Oxford Partnership Comprehensive Biomedical Research Centre, with funding from the Department of Health's National Institute for Health Research Biomedical Research Centre. This work was additionally supported by the Australian Heart Foundation.

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Copyright information

© American Aging Association 2013

Authors and Affiliations

  • Ion Codreanu
    • 1
    Email author
  • Tammy J. Pegg
    • 2
  • Joseph B. Selvanayagam
    • 3
  • Matthew D. Robson
    • 2
  • Oliver J. Rider
    • 2
  • Constantin A. Dasanu
    • 4
  • Bernd A. Jung
    • 5
  • David P. Taggart
    • 6
  • Stephen J. Golding
    • 7
  • Kieran Clarke
    • 1
  • Cameron J. Holloway
    • 1
    • 2
    • 8
  1. 1.Department of Physiology, Anatomy and GeneticsUniversity of OxfordOxfordUK
  2. 2.University of Oxford Centre for Clinical Magnetic Resonance ResearchOxfordUK
  3. 3.Department of Cardiovascular MedicineFlinders UniversityBedford ParkAustralia
  4. 4.Saint Francis Hospital and Medical CenterHartfordUSA
  5. 5.Department of Diagnostic Radiology, Medical PhysicsUniversity HospitalFreiburgGermany
  6. 6.Department of Cardiothoracic SurgeryJohn Radcliffe HospitalOxfordUK
  7. 7.MRI Centre, John Radcliffe HospitalUniversity of OxfordOxfordUK
  8. 8.St.Vincent’s HospitalSydneyAustralia

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