, Volume 35, Issue 6, pp 2477–2483 | Cite as

Association between polymorphisms in the TRHR gene, fat-free mass, and muscle strength in older women

  • Cláudia C. LunardiEmail author
  • Ricardo M. Lima
  • Rinaldo W. Pereira
  • Tailce K. M. Leite
  • Ana B. M. Siqueira
  • Ricardo J. Oliveira


A previous genome-wide association study suggested that polymorphisms in the thyrotrophin-releasing hormone receptor (TRHR) gene contribute to fat-free mass (FFM) variation. The aim of the present study was to examine the association between polymorphisms in the TRHR gene with FFM and muscle strength in older women. Volunteers (n = 241; age = 66.65 ± 5.5 years) underwent quadriceps strength assessment using isokinetics and fat-free mass by dual-energy X-ray absorptiometry. TRHR polymorphisms and ancestry-informative markers were genotyped through standard procedures. No significant difference was observed for rs7832552. Regarding the rs16892496, ANCOVA revealed that appendicular fat-free mass (AFFM) and relative AFFM were significantly different between groups (p = 0.04 and p = 0.05, respectively). Individuals carrying A/A and A/C genotypes respectively showed, on average, an extra 1 kg and 900 g of AFFM when compared to C/C genotype carriers. Also, the C/C genotype group presented a significantly higher chance to have reduced muscle strength. The observations presented here provide further evidence that the rs16892496 polymorphism in the TRHR gene may play a role in FFM variation. Moreover, the results bring the novel insight that this genetic variant can present a modest contribution to muscle strength in older women.


Aging Sarcopenia Genetic variation 



We thank the participants of the study. Funding was provided by a grant 193.000.555/2009 from the Research Support Foundation of the Federal District (FAP-DF) and by a grant from the National Council for Scientific and Technological Development (CNPq).


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Copyright information

© American Aging Association 2013

Authors and Affiliations

  • Cláudia C. Lunardi
    • 1
    Email author
  • Ricardo M. Lima
    • 3
  • Rinaldo W. Pereira
    • 2
  • Tailce K. M. Leite
    • 2
  • Ana B. M. Siqueira
    • 2
  • Ricardo J. Oliveira
    • 3
  1. 1.College of Physical EducationUniversity of BrasiliaBrasíliaBrazil
  2. 2.College of Physical EducationCatholic University of BrasiliaBrasiliaBrazil
  3. 3.College of Physical EducationUniversity of BrasiliaBrasíliaBrazil

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