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Association of sleep quality and dementia among long-lived Chinese older adults

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Abstract

In this study, we examined the existence of relationship between sleep quality and dementia in subjects aged 90 years and above. The sample included 216 men and 444 women. Dementia and sleep quality were measured with 30-item mini-mental state examination (MMSE) and the Pittsburgh sleep quality index, respectively. Subjects with dementia had higher sleep quality score (7.83 ± 2.15 vs. 5.22 ± 2.49; P < 0.0001), longer sleep latency (50.97 ± 21.33 vs. 37.61 ± 12.53; P < 0.0001), and a lower sleep efficiency percentage (73.95 ± 8.783 vs. 81.32 ± 10.21; P < 0.0001) and more likely to report poor sleep quality (25.42 vs.17.13 %; P = 0.035). Subjects with poor sleep quality had significantly lower MMSE scores (P = 0.007) and higher prevalence of dementia (P = 0.042). Multiple logistic regressions were performed by adjusting clinical factors that are thought to be associated with dementia or sleep quality. We found that poor sleep quality was a risk factor for dementia (unadjusted odds ratio (OR) 1.719, 95 % confidence interval (CI) 1.138–2.597; adjusted OR 1.759, 95 % CI 1.012–3.057). There was no significant difference in MMSE scores (11.25 ± 3.40, 16.26 ± 5.14, and 15.43 ± 5.51; P = 0.105) among participants with daily average sleep durations of <5, 5–9, and >9 h, respectively. Among Chinese nonagenarians and centenarians, dementia was correlated with poor sleep quality, longer sleep latency, and lower sleep efficiency percentage.

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Acknowledgments

This work was supported by the Discipline Construction Foundation of Sichuan University and by grants from the Project of Science and Technology Bureau of Sichuan Province (2006Z09-006-4) and the Construction Fund for Subjects of West China Hospital of Sichuan University (XK05001). The authors would like to thank the staff of the Department of Geriatrics Medicine, West China Hospital and Dujiangyan Hospital, and all participants (as well as their legal proxies) for their great contribution. Dr. Joey Kwong (the Chinese University of Hong Kong, Hong Kong) is especially acknowledged for his language assistance.

Author information

Correspondence to Dong Bi-Rong.

Additional information

Yue Jirong and Huang Changquan contributed equally to the current study.

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Cite this article

Jirong, Y., Changquan, H., Hongmei, W. et al. Association of sleep quality and dementia among long-lived Chinese older adults. AGE 35, 1423–1432 (2013). https://doi.org/10.1007/s11357-012-9432-8

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Keywords

  • Dementia
  • Sleep quality
  • Sleep duration
  • Nonagenarians
  • Centenarians