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AGE

, Volume 35, Issue 3, pp 905–920 | Cite as

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

  • Carissa J. Murrell
  • James D. Cotter
  • Kate N. Thomas
  • Samuel J. E. Lucas
  • Michael J. A. Williams
  • Philip N. Ainslie
Article

Abstract

Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO2 are risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher CBF at any age; however, whether CBF or reactivity can be elevated following an exercise training intervention in healthy individuals is unknown. The aim of this study was to assess the effect of exercise training on CBF and cerebrovascular reactivity at rest and during exercise in young and older individuals. Ten young (23 ± 5 years; body mass index (BMI), 26 ± 3 kg m−2; \( {\mathop{V}\limits^{ \cdot }{_{\text{O2}}}}\max \), 35 ± 5 ml kg−1 min−1) and 10 older (63 ± 5 years; BMI, 25 ± 3.0 kg m−2; \( {\mathop{V}\limits^{ \cdot }{_{\text{O2}}}}\max \), 26 ± 4 ml kg-1 min−1) previously sedentary individuals breathed 5 % CO2 for 3 min at rest and during steady-state cycling exercise (30 and 70 % heart rate range (HRR)) prior to and following a 12-week aerobic exercise intervention. Effects of training on middle cerebral artery blood velocity (MCAv) at rest were unclear in both age groups. The absolute MCAv response to exercise was greater in the young (9 and 9 cm s−1 (30 and 70 % HRR, respectively) vs. 5 and 4 cm s−1 (older), P < 0.05) and was similar following training. Cerebrovascular reactivity was elevated following the 12-week training at rest (2.87 ± 0.76 vs. 2.54 ± 1.12 cm s−1 mm Hg−1, P = 0.01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing.

Keywords

Ageing Exercise training Fitness Cerebral blood flow CO2 reactivity 

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Copyright information

© American Aging Association 2012

Authors and Affiliations

  • Carissa J. Murrell
    • 1
  • James D. Cotter
    • 2
  • Kate N. Thomas
    • 1
  • Samuel J. E. Lucas
    • 1
  • Michael J. A. Williams
    • 3
  • Philip N. Ainslie
    • 4
  1. 1.Department of PhysiologyUniversity of OtagoDunedinNew Zealand
  2. 2.School of Physical EducationUniversity of OtagoDunedinNew Zealand
  3. 3.Department of MedicineUniversity of OtagoDunedinNew Zealand
  4. 4.School of Health and Exercise SciencesUniversity of British ColumbiaKelownaCanada

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