AGE

, Volume 31, Issue 4, pp 285–291

KLRG1—more than a marker for T cell senescence

Article

DOI: 10.1007/s11357-009-9100-9

Cite this article as:
Henson, S.M. & Akbar, A.N. AGE (2009) 31: 285. doi:10.1007/s11357-009-9100-9

Abstract

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.

Keywords

KLRG1 Inhibitory ITIM Highly differentiated T cell 

Copyright information

© American Aging Association, Media, PA, USA 2009

Authors and Affiliations

  1. 1.Division of Infection and Immunity, Department of ImmunologyUniversity College LondonLondonUK

Personalised recommendations