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AGE

, Volume 31, Issue 4, pp 269–276 | Cite as

Nitrones for understanding and ameliorating the oxidative stress associated with aging

  • Siham El Fangour
  • Milvia Marini
  • James Good
  • Stephen J. McQuaker
  • Paul G. Shiels
  • Richard C. HartleyEmail author
Article

Abstract

Oxidative damage from reactive oxygen species (ROS) and the carbon-centred radicals arising from them is important to the process of aging, and age-related diseases are generally caused, exacerbated or mediated by oxidative stress. Nitrones can act as spin traps to detect, identify, quantify and locate the radicals responsible using electron paramagnetic resonance (EPR or ESR) spectroscopy, and a new carnitine-derived nitrone, CarnDOD-7C, designed to accumulate in mitochondria is reported. Nitrones also have potential as therapeutic antioxidants, e.g. for slowing cellular aging, and as tools for chemical biology. Two low-molecular weight nitrones, DIPEGN-2 and DIPEGN-3, are reported, which combine high water-solubility with high lipophilicity and obey Lipinski's rule of five.

Keywords

Aging Oxidative stress Reactive oxygen species Radicals Electron paramagnetic resonance spectroscopy Nitrones Antioxidants 

Notes

Acknowledgements

Scottish Enterprise for Proof of Concept funding. SPARC and the BBSRC for the purchase of the bench-top EPR spectrometer used.

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Copyright information

© American Aging Association, Media, PA, USA 2009

Authors and Affiliations

  • Siham El Fangour
    • 1
  • Milvia Marini
    • 2
  • James Good
    • 1
  • Stephen J. McQuaker
    • 1
  • Paul G. Shiels
    • 3
  • Richard C. Hartley
    • 1
    Email author
  1. 1.Centre for the Chemical Research of Ageing, WestCHEM Department of ChemistryUniversity of GlasgowGlasgowUK
  2. 2.Dipartimento di Scienze e ChimicheUniversità Politecnica delle MarcheAnconaItaly
  3. 3.Department of SurgeryUniversity of GlasgowGlasgowUK

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