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AGE

, Volume 30, Issue 4, pp 251–261 | Cite as

Aging of the striatum: mechanisms and interventions

  • Hiroyuki UmegakiEmail author
  • George S. Roth
  • Donald K. Ingram
Article

Abstract

Motor function declines with increasing adult age. Proper regulation of the balance between dopamine (DA) and acetylcholine (ACh) in the striatum has been shown to be fundamentally important for motor control. Although other factors can also contribute to this age-associated decline, a decrease in the concentration and binding potential of the DA D2 receptor subtype in the striatum, especially in the cholinergic interneurons, are involved in the mechanism. Our studies have shown that gene transfer of the DA D2 receptor subtype with adenoiviral vectors is effective in ameliorating age-associated functional decline of the striatal cholinergic interneurons. These achievements confirm that an age-associated decrease of D2R contributes functional alteration of the interaction of DA and ACh in the striatum and demonstrate that these age-associated changes indeed are modifiable.

Keywords

Dopamine receptor D2 Viral vector Acetylcholine Interneuron 

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Copyright information

© American Aging Association, Media, PA, USA 2008

Authors and Affiliations

  • Hiroyuki Umegaki
    • 1
    Email author
  • George S. Roth
    • 2
  • Donald K. Ingram
    • 3
  1. 1.Department of GeriatricsNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.GeroScience, Inc.PylesvilleUSA
  3. 3.Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research CenterLouisiana State University SystemBaton RougeUSA

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