Twenty years of progress in biogerontology research
- First Online:
The first 10 years of NIA's existence were characterized by funding for descriptive and discovery research, as the field had not yet come of age. As Couzin expressed it in the July 1, 2005 issue of Science, “Just 2 or 3 decades ago, research on aging was a backwater” (Couzin J 2005 How much can human life span be extended. Science 309: 83). With the isolation of long-lived animal mutants and the application of the tools of molecular biology and transgenic technology to biogerontology research, the situation has changed dramatically since then, and aging research has become increasingly mechanistic and respectable. This transition has been aided by some well-thought out research initiatives by the NIA, and the purpose of this article is to provide a brief summary of the progress made in the past 20 years, and describe the part that NIA initiatives and funding have played in this transition.
Unable to display preview. Download preview PDF.
- Campisi J (2002) Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol 38: 5–11Google Scholar
- Ikeno Y, Bronson RT, Hubbard GB, Lee S and Bartke A (2002) Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity. J Gerontol 58: 291–296Google Scholar
- Luckinbill L, Arking R and Clare M (1984) Selection for delayed senescence in Drosophila melanogaster. Evolution 38: 996–1003Google Scholar
- McCay CM, Crowell MF and Maynard LA (1935) The effect of retarded growth upon the length of life span and upon ultimate body size. J Nutr 10: 63–79Google Scholar
- Miggliaccio E, Giorgio M, Mele S, Pelicci G, Reholdi P and Pandolfi PP et al. (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402: 309–313Google Scholar
- Mishkin R and Masos T (1997) Transgenic mice over-expressing urokinase-type plasminogen activator in brain exhibit reduced food consumption, body weight and increased longevity. J Gerontol 52:B118–B124Google Scholar
- Rose MR (1984) Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution 38: 1004–1010Google Scholar
- Staba SL, Escolar ML, Poe M, Kim Y, Martin PL and Szabolcs Pet al. (2004) Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Eng J Med 350: 1960– 1969Google Scholar
- Weindruch R and Walford RL (1988) The Retardation of Aging and Disease by Dietary Restriction. C.C. Thomas, Springfield, IllinoisGoogle Scholar