Journal of the American Aging Association

, Volume 23, Issue 2, pp 103–115 | Cite as

Endocrine and metabolic changes in human aging



Numerous alterations in hormonal secretion occur with aging. In general, these tend towards a disintegration of the normal cyclic secretory patterns resulting in lower total circulating levels. In addition, declines in receptors and postreceptor function further decreases the ability of the hormonal orchestra to maintain coordinated function throughout the organism. Clues to some of these age-related changes in humans may come from the study of simpler organisms where regulatory systems are known to modulate the aging process. In particular, the interactions among the environment, hormones, and insulin receptor genes have led to new insights into the genetic control of longevity and the development of syndrome X.


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Copyright information

© American Aging Association, Inc. 2000

Authors and Affiliations

  1. 1.Division of Geriatric MedicineSaint Louis University Medical SchoolSt. Louis
  2. 2.Geriatric Research, Education and Clinical CenterSt. Louis VAMCSt. Louis

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