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Movento effects on learning and hippocampal brain-derived neurotrophic factor protein of adult male rats

  • Iman Zangiabadi
  • Mohammad Reza AfarineshEmail author
  • Ali Shamsara
  • Seyed Hasan Eftekhar-VaghefiEmail author
Research Article

Abstract

Spirotetramat is a toxic commercially known as Movento used to control pistachio psylla pests. In the present study, the effects of Movento on passive avoidance learning of rats and their ability to explore the novel object in the novel object recognition test were investigated. The changes in the concentration of hippocampal brain-derived neurotrophic factor (BDNF) proteins were evaluated, too. Male Wistar rats were gavaged at different dosages of the Movento (50, 100, 250, 500, 1000, 1250, and 1500 mg/kg) or saline for 7 days (administered every 2 days). We showed that Movento caused 50 and 100% mortality at the dose of 1250 and 1500 mg/kg, respectively. At the dose of 1000 mg/kg, Movento significantly decreased locomotor activity (P < 0.05). These rats also displayed a significant decrease in the number of training trials in the shuttle box and the ability to recognize a novel object compared with the control group (P < 0.01). The BDNF protein level of hippocampus also showed a significant decrease in the Movento (1000 mg/kg) compared with the control group (P < 0.01) while the number of pancellular necrosis pyramidal CA1 cells increased significantly in the Movento group (P < 0.001). We concluded that exposure to Movento can decline sensory, motor, and learning in rats.

Keywords

Spirotetramat Movento Learning Memory Rat 

Notes

Acknowledgments

This study is extracted from the dissertation of Mr. Iman Zangiabadi as a submitted proposal under ethical code number of IR.KMU.REC.1397.255. The authors also appreciate collaboration of KNRC.

Funding information

This paper received support from the Kerman Neuroscience Research Center (EC/KNRC/95-43).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Anatomy, School of MedicineKerman University of Medical SciencesKermanIran
  2. 2.Kerman Neuroscience Research Center, Institute of NeuropharmachologyKerman University of Medical SciencesKermanIran
  3. 3.Kerman Cognitive Neuroscience Research Center, Institute of NeuropharmachologyKerman University of Medical SciencesKermanIran
  4. 4.Department of Anatomy, Kerman BranchIslamic Azad UniversityKermanIran

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