An overview of research trends and genetic polymorphisms for noise-induced hearing loss from 2009 to 2018

  • Long Miao
  • Jiahui Ji
  • Liu Wan
  • Juan Zhang
  • Lihong Yin
  • Yuepu PuEmail author
Review Article


Recently, there has been increased studies in noise-induced hearing loss (NIHL). We aimed to make an overview of research trends and genetic polymorphisms for NIHL from 2009 to 2018 with VOSviewer software. A total of 2391 papers were identified for research trends analysis in NIHL and 33 studies identified for a brief review of genetic polymorphisms in human NIHL. The number of publications has been increasing over the past decade. The journal Hearing Research published the most articles (218). The USA contributed the largest number of papers (1042; 43.58%), with the most citations (18,987) and the highest H-index (60). The University of Washington was the most contributive institution. Liberman MC published the most articles (32), and Kujawa SG possessed the highest co-citations (584). Except for high-frequency keywords identified by the software, “prevalence,” “oxidative stress,” “hair cells,” and “cochlear implant” were also the latest research frontiers. HSPA1A rs1043618, HSPA1L rs2227956, PON2 rs12026 and rs7785846, SOD2 rs2855116, KCNE1 rs2070358, KCNQ4 rs34287852, GJB2 rs3751385, PCDH15 rs7095441 and rs11004085, GRHL2 rs1981361, ITGA8 rs10508489, MYH14 rs667907, and POU4F3 rs891969 were the research hotspots and were replicated in independent samples. Inflammation response underlying NIHL has emerged and should be considered as a pioneering field in the future for the prevention of NIHL and conservation of hearing.


Noise-induced hearing loss Bibliometrics Overview Polymorphism VOSviewer WoSCC 



The authors would like to thank Dr. Yan Miao for his help in bibliometric analysis.

Funding information

This study was funded by the Jiangsu Preventive Medicine Foundation (Y2015049).


  1. Abi-Hachem RN, Zine A, Van De Water TR (2010) The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies. Recent Pat CNS Drug Discov 5:147–163CrossRefGoogle Scholar
  2. Basner M, Babisch W, Davis A, Brink M, Clark C, Janssen S, Stansfeld S (2014) Auditory and non-auditory effects of noise on health. Lancet 383:1325–1332CrossRefGoogle Scholar
  3. Braga MP, Maciel SM, Marchiori LL, Poli-Frederico RC (2014) Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure. Braz J Otorhinolaryngol 80:373–378CrossRefGoogle Scholar
  4. Carroll YI, Eichwald J, Scinicariello F, Hoffman HJ, Deitchman S, Radke MS, Themann CL, Breysse P (2017) Vital signs: noise-induced hearing loss among adults - United States 2011-2012. MMWR Morb Mortal Wkly Rep 66:139–144CrossRefGoogle Scholar
  5. Carvalho LC, Marchiori LL, Melo JJ, Maciel SM, Poli-Frederico RC (2013) Interleukin-1beta gene polymorphism and hearing loss related to the history of occupational noise exposure in Brazilian elderly. Noise Health 15:160–164CrossRefGoogle Scholar
  6. Chang NC, Ho CK, Wu MT, Yu ML, Ho KY (2009) Effect of manganese-superoxide dismutase genetic polymorphisms IVS3-23T/G on noise susceptibility in Taiwan. Am J Otolaryngol 30:396–400CrossRefGoogle Scholar
  7. Chang NC, Ho CK, Lin HY, Yu ML, Chien CY, Ho KY (2011) Association of polymorphisms of heat shock protein 70 with susceptibility to noise-induced hearing loss in the Taiwanese population. Audiol Neurootol 16:168–174CrossRefGoogle Scholar
  8. Costas R, Bordons M (2007) The h-index: Advantages, limitations and its relation with other bibliometric indicators at the micro level. J Informetr 1:193–203CrossRefGoogle Scholar
  9. Dabdoub A, Nishimura K (2017) Cochlear implants meet regenerative biology: state of the science and future research directions. Otol Neurotol 38:e232–e236CrossRefGoogle Scholar
  10. Ding E, Liu J, Guo H, Shen H, Zhang H, Gong W, Song H, Zhu B (2018a) DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers. Sci Rep 8:12193CrossRefGoogle Scholar
  11. Ding E, Liu J, Shen H, Gong W, Zhang H, Song H, Zhu B (2018b) Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers. BMC Med Genet 19:168CrossRefGoogle Scholar
  12. Ekinci S, Agilli M, Ersen O, Ekinci GH (2015) Letter to the editor regarding analysis of changing paradigms of management in 179 patients with spinal tuberculosis during a 12-year period and proposal of a new management algorithm. World Neurosurg 84:2072CrossRefGoogle Scholar
  13. Fetoni AR, Paciello F, Rolesi R, Paludetti G, Troiani D (2019) Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling. Free Radic Biol Med 135:46–59CrossRefGoogle Scholar
  14. Fuentes-Santamaria V, Alvarado JC, Melgar-Rojas P, Gabaldon-Ull MC, Miller JM, Juiz JM (2017) The Role of Glia in the Peripheral and Central Auditory System Following Noise Overexposure: Contribution of TNF-alpha and IL-1beta to the Pathogenesis of Hearing Loss. Front Neuroanat 11:9CrossRefGoogle Scholar
  15. Garfield E (1987) 100 citation classics from the Journal of the American Medical Association. JAMA 257:52–59CrossRefGoogle Scholar
  16. Garfield E (2006) The history and meaning of the journal impact factor. JAMA 295:90–93CrossRefGoogle Scholar
  17. Guo H, Ding E, Bai Y, Zhang H, Shen H, Wang J, Song X, Cai W, Guo J, Zhu B (2017) Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population. PLoS One 12:e0189186CrossRefGoogle Scholar
  18. Guo H, Ding E, Sheng R, Cheng J, Cai W, Guo J, Wang N, Zhang H, Zhu B (2018) Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population. Environ Toxicol Pharmacol 63:55–59CrossRefGoogle Scholar
  19. Henderson D, Bielefeld EC, Harris KC, Hu BH (2006) The role of oxidative stress in noise-induced hearing loss. Ear Hear 27:1–19CrossRefGoogle Scholar
  20. Hormozi M, Ansari-Moghaddam A, Mirzaei R, Dehghan Haghighi J, Eftekharian F (2017) The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: a systematic review and meta-analysis. Int J Occup Med Environ Health 30:521–535Google Scholar
  21. Hu F, Li X, Li X, Wang M, Chu H, Liu K, Zhang H, Zhang Z, Zhu B (2013) Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population. Noise Health 15:231–236CrossRefGoogle Scholar
  22. Konings A, Van Laer L, Michel S, Pawelczyk M, Carlsson PI, Bondeson ML, Rajkowska E, Dudarewicz A, Vandevelde A, Fransen E, Huyghe J, Borg E, Sliwinska-Kowalska M, Van Camp G (2009a) Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. Eur J Hum Genet 17:329–335CrossRefGoogle Scholar
  23. Konings A, Van Laer L, Wiktorek-Smagur A, Rajkowska E, Pawelczyk M, Carlsson PI, Bondeson ML, Dudarewicz A, Vandevelde A, Fransen E, Huyghe J, Borg E, Sliwinska-Kowalska M, Van Camp G (2009b) Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations. Ann Hum Genet 73:215–224CrossRefGoogle Scholar
  24. Kowalski TJ, Pawelczyk M, Rajkowska E, Dudarewicz A, Sliwinska-Kowalska M (2014) Genetic variants of CDH23 associated with noise-induced hearing loss. Otol Neurotol 35:358–365CrossRefGoogle Scholar
  25. Kuhlenbaumer G, Hullmann J, Appenzeller S (2011) Novel genomic techniques open new avenues in the analysis of monogenic disorders. Hum Mutat 32:144–151CrossRefGoogle Scholar
  26. Kujawa SG, Liberman MC (2009) Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss. J Neurosci 29:14077–14085CrossRefGoogle Scholar
  27. Li X, Huo X, Liu K, Li X, Wang M, Chu H, Hu F, Sheng H, Zhang Z, Zhu B (2013a) Association between genetic variations in GRHL2 and noise-induced hearing loss in Chinese high intensity noise exposed workers: a case-control analysis. Ind Health 51:612–621CrossRefGoogle Scholar
  28. Li XT, Li X, Hu FF, Shen HX, Cao JL, Li Z, Zhang ZD, Zhu BL (2013b) Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population. J Occup Health 55:56–65CrossRefGoogle Scholar
  29. Li X, Cao J, Wang J, Song H, Ji G, Dong Q, Wei C, Cao Y, Wang B, Zhu B, Xiao H (2016) PON2 and ATP2B2 gene polymorphisms with noise-induced hearing loss. J Thorac Dis 8:430–438CrossRefGoogle Scholar
  30. Li Y, Yu S, Gu G, Chen G, Zheng Y, Jiao J, Zhou W, Wu H, Zhang Z, Zhang H, He L, Yang Q, Xu X (2017) Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: a case-control study. PLoS One 12:e0171722CrossRefGoogle Scholar
  31. Liu YM, Li XD, Guo X, Liu B, Lin AH, Ding YL, Rao SQ (2010a) SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Dis Markers 28:137–147CrossRefGoogle Scholar
  32. Liu YM, Li XD, Guo X, Liu B, Lin AH, Rao SQ (2010b) Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers. Acta Otolaryngol 130:477–486CrossRefGoogle Scholar
  33. Masterson EA, Tak S, Themann CL, Wall DK, Groenewold MR, Deddens JA, Calvert GM (2013) Prevalence of hearing loss in the United States by industry. Am J Ind Med 56:670–681CrossRefGoogle Scholar
  34. Masterson EA, Bushnell PT, Themann CL, Morata TC (2016) Hearing impairment among noise-exposed workers - United States, 2003-2012. MMWR Morb Mortal Wkly Rep 65:389–394CrossRefGoogle Scholar
  35. Miao Y, Zhang Y, Yin L (2018) Trends in hepatocellular carcinoma research from 2008 to 2017: a bibliometric analysis. PeerJ 6:e5477CrossRefGoogle Scholar
  36. Nelson DI, Nelson RY, Concha-Barrientos M, Fingerhut M (2005) The global burden of occupational noise-induced hearing loss. Am J Ind Med 48:446–458CrossRefGoogle Scholar
  37. Ohinata Y, Yamasoba T, Schacht J, Miller JM (2000) Glutathione limits noise-induced hearing loss. Hear Res 146:28–34CrossRefGoogle Scholar
  38. Ohlemiller KK, McFadden SL, Ding DL, Flood DG, Reaume AG, Hoffman EK, Scott RW, Wright JS, Putcha GV, Salvi RJ (1999) Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol 4:237–246CrossRefGoogle Scholar
  39. Pawelczyk M, Van Laer L, Fransen E, Rajkowska E, Konings A, Carlsson PI, Borg E, Van Camp G, Sliwinska-Kowalska M (2009) Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss. Ann Hum Genet 73:411–421CrossRefGoogle Scholar
  40. Samanci Y, Samanci B, Sahin E (2019) Bibliometric analysis of the top-cited articles on idiopathic intracranial hypertension. Neurol India 67:78–84CrossRefGoogle Scholar
  41. Shen H, Huo X, Liu K, Li X, Gong W, Zhang H, Xu Y, Wang M, Li X, Zhang J, Zhang Z, Zhu B (2012) Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population. J Occup Environ Med 54:1157–1162CrossRefGoogle Scholar
  42. Shen H, Cao J, Hong Z, Liu K, Shi J, Ding L, Zhang H, Du C, Li Q, Zhang Z, Zhu B (2014) A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population. PLoS One 9:e89662CrossRefGoogle Scholar
  43. Shen H, Dou J, Han L, Bai Y, Li Q, Hong Z, Shi J, Zhang H, Zhang F, Du C, Tong Z, Zhu B (2016) Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population. Int Arch Occup Environ Health 89:621–628CrossRefGoogle Scholar
  44. Singh PK, Chandra G, Bogra J, Gupta R, Kumar V, Jain A, Hussain SR, Mahdi AA, Ahmad MK (2015) Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population. Meta Gene 4:142–151CrossRefGoogle Scholar
  45. Sliwinska-Kowalska M, Pawelczyk M (2013) Contribution of genetic factors to noise-induced hearing loss: a human studies review. Mutat Res 752:61–65CrossRefGoogle Scholar
  46. Tak S, Davis RR, Calvert GM (2009) Exposure to hazardous workplace noise and use of hearing protection devices among US workers--NHANES, 1999-2004. Am J Ind Med 52:358–371CrossRefGoogle Scholar
  47. Tan WJ, Thorne PR, Vlajkovic SM (2016) Characterisation of cochlear inflammation in mice following acute and chronic noise exposure. Histochem Cell Biol 146:219–230CrossRefGoogle Scholar
  48. Thorne PR, Nuttall AL, Scheibe F, Miller JM (1987) Sound-induced artifact in cochlear blood flow measurements using the laser Doppler flowmeter. Hear Res 31:229–234CrossRefGoogle Scholar
  49. Van Laer L, Carlsson PI, Ottschytsch N, Bondeson ML, Konings A, Vandevelde A, Dieltjens N, Fransen E, Snyders D, Borg E, Raes A, Van Camp G (2006) The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. Hum Mutat 27:786–795CrossRefGoogle Scholar
  50. van Raan AF, Visser MS, Van Leeuwen TN, van Wijk E (2003) Bibliometric analysis of psychotherapy research: performance assessment and position in the journal landscape. Psychother Res 13:511–528CrossRefGoogle Scholar
  51. Wang SL, Yu LG, Liu RP, Zhu WZ, Gao WM, Xue LP, Jiang X, Zhang YH, Yi D, Chen D, Zhang YH (2014) Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population. Biomed Environ Sci 27:965–968Google Scholar
  52. Wang B, Ding E, Shen H, Wang J, Sun K, Chen S, Han L, Zhang H, Zhu B, Xu M (2017a) Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population. Hear Res 347:41–46CrossRefGoogle Scholar
  53. Wang Y, Wang Q, Wei X, Shao J, Zhao J, Zhang Z, Chen Z, Bai Y, Wang N, Wang Y, Li M, Zhai X (2017b) Global scientific trends on exosome research during 2007-2016: a bibliometric analysis. Oncotarget 8:48460–48470Google Scholar
  54. Wangemann P (2002) K+ cycling and the endocochlear potential. Hear Res 165:1–9CrossRefGoogle Scholar
  55. Wu Y, Ni J, Qi M, Cao C, Shao Y, Xu L, Ma H, Yang L (2017) Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case-control study. Environ Health 16:78CrossRefGoogle Scholar
  56. Xia G, Gao W, Ji K, Liu S, Wan B, Luo J, Bai Y (2011) Single nucleotide polymorphisms analysis of noise-induced hearing loss using three-dimensional polyacrylamide gel-based microarray method. J Biomed Nanotechnol 7:807–812CrossRefGoogle Scholar
  57. Xu X, Yang Q, Jiao J, He L, Yu S, Wang J, Gu G, Chen G, Zhou W, Wu H, Li Y, Zhang H (2016) Genetic Variation in POU4F3 and GRHL2 Associated with noise-induced hearing loss in Chinese population: a case-control study. Int J Environ Res Public Health 13CrossRefGoogle Scholar
  58. Yang J, Zhang J, Wang X, Wang C, Chen J, Qian Y, Duan Z (2015) Identification of functional tag single nucleotide polmorphisms within the entire CAT gene and their clinical relevance in patients with noise-induced hearing loss. Int J Clin Exp Pathol 8:2852–2863Google Scholar
  59. Yang Q, Xu X, Jiao J, Zheng Y, He L, Yu S, Gu G, Chen G, Zhou W, Wu H, Li Y, Zhang H, Zhang Z (2016) Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample. Occup Environ Med 73:823–828Google Scholar
  60. Yu SF (2016) Strengthen the research for the prevention and control of occupational noise-induced hearing loss in our country. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 34:881–883Google Scholar
  61. Yu P, Jiao J, Chen G, Zhou W, Zhang H, Wu H, Li Y, Gu G, Zheng Y, Yu Y, Yu S (2018) Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study. BMC Med Genet 19:4CrossRefGoogle Scholar
  62. Yuan BC, Su FM, Wu WT, Liu WS, Chiu KH (2012) A predictive model of the association between gene polymorphism and the risk of noise-induced hearing loss caused by gunfire noise. J Chin Med Assoc 75:36–39CrossRefGoogle Scholar
  63. Zhai X, Cui J, Shao J, Wang Q, Chen X, Wei X, Zhou X, Chen Z, Bai Y, Li M (2017) Global research trends in spinal ultrasound: a systematic bibliometric analysis. BMJ Open 7:e015317CrossRefGoogle Scholar
  64. Zhang X, Liu Y, Zhang L, Yang Z, Shao Y, Jiang C, Wang Q, Fang X, Xu Y, Wang H, Zhang S, Zhu Y (2014) Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population. Environ Res 135:247–252CrossRefGoogle Scholar
  65. Zhang X, Liu Y, Zhang L, Yang Z, Yang L, Wang X, Jiang C, Wang Q, Xia Y, Chen Y, Wu O, Zhu Y (2015) Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study. Environ Health 14:77CrossRefGoogle Scholar
  66. Zorov DB, Juhaszova M, Sollott SJ (2014) Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 94:909–950CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Long Miao
    • 1
  • Jiahui Ji
    • 1
  • Liu Wan
    • 1
  • Juan Zhang
    • 1
  • Lihong Yin
    • 1
  • Yuepu Pu
    • 1
    Email author
  1. 1.Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public HealthSoutheast UniversityNanjingPeople’s Republic of China

Personalised recommendations