Association between prenatal exposure to perfluoroalkyl substances and asthma-related diseases in preschool children

  • Xinxin Zeng
  • Qian Chen
  • Xi Zhang
  • Huajun Li
  • Quanhua Liu
  • Chunxiao Li
  • Ming Ma
  • Jianhua Zhang
  • Weixi ZhangEmail author
  • Jun ZhangEmail author
  • Lisu HuangEmail author
Research Article


Thus far, the few studies on the associations between perfluoroalkyl substances (PFASs) and asthma in children have yielded inconsistent results. In this study, we aimed to evaluate whether and to what extent prenatal PFASs exposure is associated with childhood asthmatic diseases. Eight PFASs were measured in cord blood drawn from 358 children in the Shanghai Allergy Birth Cohort, and a 5-year follow-up plan was completed. Asthma was diagnosed and reported by pediatric respiratory physicians via repeated symptoms (wheezing and coughing) and laboratory examination (Immunoglobulin E level test and skin prick test). A total of 26.6% and 17.4% subjects were diagnosed with wheezing and asthma, respectively. Multivariable logistic regression and piecewise linear regression were applied, and no association was found between PFASs and asthma or wheezing. However, cord serum PFOA, PFOS, and PFDA were positively correlated with serum total IgE in 5-year-old children as the level of the former beyond the turning point (4.37 ng/mL, 2.95 ng/mL, and 0.42 ng/mL, respectively), but negatively with IgE before it reach turnning point.


Perfluoroalkyl substances Prenatal exposure Asthma Immunoglobulin E Birth cohort study 



We thank all officers and staff of the birth cohort study and the physicians at the Xinhua Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine.

Ethics approval and consent to participate

The ethics approval was obtained from the Xinhua Hospital and International Peace Maternity and Infant Health Hospital affiliated to the Shanghai Jiao Tong University School of Medicine. This study was conducted in accordance with the principles of the Helsinki Declaration.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Funding information

This investigation was supported by National Natural Science Foundation of China (No. 81530086), Shanghai Municipal Health Commission (No. 2017YQ033), Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents, Provincial Natural Science Foundation of Zhejiang (No. LY15H010006), and Zhejiang Provincial Department of Science and Technology Project (No. 2016C33182).

Supplementary material

11356_2019_5864_MOESM1_ESM.docx (75 kb)
ESM 1 (DOCX 74 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pediatrics Infectious Diseases, Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Department of Pediatric Allergy and ImmunologyThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina
  3. 3.MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  4. 4.Clinical Research Center, Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  5. 5.Department of Dermatological, Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina

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