Association between prenatal exposure to perfluoroalkyl substances and asthma-related diseases in preschool children
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Thus far, the few studies on the associations between perfluoroalkyl substances (PFASs) and asthma in children have yielded inconsistent results. In this study, we aimed to evaluate whether and to what extent prenatal PFASs exposure is associated with childhood asthmatic diseases. Eight PFASs were measured in cord blood drawn from 358 children in the Shanghai Allergy Birth Cohort, and a 5-year follow-up plan was completed. Asthma was diagnosed and reported by pediatric respiratory physicians via repeated symptoms (wheezing and coughing) and laboratory examination (Immunoglobulin E level test and skin prick test). A total of 26.6% and 17.4% subjects were diagnosed with wheezing and asthma, respectively. Multivariable logistic regression and piecewise linear regression were applied, and no association was found between PFASs and asthma or wheezing. However, cord serum PFOA, PFOS, and PFDA were positively correlated with serum total IgE in 5-year-old children as the level of the former beyond the turning point (4.37 ng/mL, 2.95 ng/mL, and 0.42 ng/mL, respectively), but negatively with IgE before it reach turnning point.
KeywordsPerfluoroalkyl substances Prenatal exposure Asthma Immunoglobulin E Birth cohort study
We thank all officers and staff of the birth cohort study and the physicians at the Xinhua Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine.
Ethics approval and consent to participate
The ethics approval was obtained from the Xinhua Hospital and International Peace Maternity and Infant Health Hospital affiliated to the Shanghai Jiao Tong University School of Medicine. This study was conducted in accordance with the principles of the Helsinki Declaration.
Conflict of Interest
The authors declare that they have no conflicts of interest.
This investigation was supported by National Natural Science Foundation of China (No. 81530086), Shanghai Municipal Health Commission (No. 2017YQ033), Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents, Provincial Natural Science Foundation of Zhejiang (No. LY15H010006), and Zhejiang Provincial Department of Science and Technology Project (No. 2016C33182).
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