Exposure to bisphenol A and diabetes risk in Mexican women
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Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, which has been previously linked to diabetes among non-Hispanic populations. As part of a case control study for breast cancer, only controls with BPA information were included in this report. The final sample size comprises 70 self-reported diabetics and 334 non-diabetics. Urinary free bisphenol A (BPA-F) (μg/L) was determined by solid-phase extraction and HPLC/FLD analysis. Logistic regression models were used to evaluate the association between BPA-F and self-reported diabetes. After adjusting by age, urinary BPA-F (4.06–224.53 μg/g creatinine) was associated with diabetes exposure (OR = 1.85; 95% CI 1.04, 3.28) compared with women in the reference category (0.67–4.05 μg/g creatinine). BPA may be an environmental cofactor of diabetes. More studies are needed to confirm this result, especially in Hispanic populations.
KeywordsDiabetes Bisphenol a BPA Endocrine-disrupting chemical Mexico Women
The authors thank Rosa María García Hernández and Guadalupe Lina García Hernández for their assistance in BPA extraction and Belen Barajas L. for literature search.
This study was partially supported by CONACYT Fondo Sectorial de Investigación en Salud y Seguridad Social 2005-2-14373, 2009-1-111384, 2010-1-140962, PDCPN 2013-01-215464 and 272632, and the Advanced Study Grant and Gabelli Presidential Scholars Programs of Boston College.
Compliance with ethical standards
The study was approved by the ethics committee of the National Institute of Public Health of Mexico.
Conflict of interest
The authors declare they have no conflicts of interest.
- Andra SS, Kalyvas H, Andrianou XD, Charisiadis P, Christophi CA, Makris KC (2015) Preliminary evidence of the association between monochlorinated bisphenol a exposure and type II diabetes mellitus: a pilot study. J Environ Sci Health A Toxic/Hazard Subst Environ Eng 50:243–259. https://doi.org/10.1080/10934529.2015.981111 CrossRefGoogle Scholar
- Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, van der Meer T, Stefaniak M, Wajid S, Doliba N, Bartolomei MS, Simmons RA (2017) Sex- and dose-specific effects of maternal bisphenol A exposure on pancreatic islets of first- and second-generation adult mice offspring. Environ Health Perspect 125:097022. https://doi.org/10.1289/EHP1674 CrossRefGoogle Scholar
- Bi Y, Wang W, Xu M, Wang T, Lu J, Xu Y, Dai M, Chen Y, Zhang D, Sun W, Ding L, Chen Y, Huang X, Lin L, Qi L, Lai S, Ning G (2016) Diabetes genetic risk score modifies effect of bisphenol a exposure on deterioration in glucose metabolism. J Clin Endocrinol Metab 101:143–150. https://doi.org/10.1210/jc.2015-3039 CrossRefGoogle Scholar
- Cantonwine D, Meeker JD, Hu H, Sánchez BN, Lamadrid-Figueroa H, Mercado-García A, Fortenberry GZ, Calafat AM, Téllez-Rojo MM (2010) Bisphenol a exposure in Mexico City and risk of prematurity : a pilot nested case control study. Environ Health 9(62):1–7. https://doi.org/10.1186/1476-069X-9-62 CrossRefGoogle Scholar
- Centers for Disease Control and Prevention (2017) National Diabetes Statistics Report: estimates of diabetes and its burden in the United States. Dep Health Hum Serv 1–20. https://doi.org/10.1177/1527154408322560
- Gutiérrez JP, Rivera-Dommarco J, Shamah-Levy T, Villalpando-Hernández S, Franco A, Cuevas-Nasu L, Romero-Martínez MH-ÁM (2012) Encuesta Nacional de Salud y Nutrición 2012. Resultados Nacionales. Instituto Nacional de Salud Pública (MX), CuernavacaGoogle Scholar
- Hernández Ávila M, Rivera Dommarco J, Shamah Levy T, Nasu LC et al (2016) Encuesta Nacional de Salud y Nutrición de Medio Camino 2016. Informe final de resultados. https://doi.org/10.21149/8593
- Junge KM, Leppert B, Jahreis S, Wissenbach DK, Feltens R, Grützmann K, Thürmann L, Bauer T, Ishaque N, Schick M, Bewerunge-Hudler M, Röder S, Bauer M, Schulz A, Borte M, Landgraf K, Körner A, Kiess W, von Bergen M, Stangl GI, Trump S, Eils R, Polte T, Lehmann I (2018) MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics 10:1–12. https://doi.org/10.1186/s13148-018-0478-z CrossRefGoogle Scholar
- Kato K, Silva MJ, Needham LL, Calafat AM (2005) Determination of 16 phthalate metabolites in urine using automated sample preparation and on-line preconcentration / high-performance liquid chromatography / tandem mass spectrometry. Anal Chem 77:2985–2991. https://doi.org/10.1021/ac0481248 CrossRefGoogle Scholar
- Shu X, Tang S, Peng C, Gao R, Yang S, Luo T, Cheng Q, Wang Y, Wang Z, Zhen Q, Hu J, Li Q (2018) Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested case–control study. Acta Diabetol 55:369–375. https://doi.org/10.1007/s00592-018-1104-4 CrossRefGoogle Scholar
- Sun Q, Cornelis MC, Townsend MK, Tobias DK, Eliassen AH, Franke AA, Hauser R, Hu FB (2014) Association of urinary concentrations of bisphenol A and phthalate metabolites with risk of type 2 diabetes: a prospective investigation in the nurses’ health study (NHS) and NHSII cohorts. Environ Health Perspect 122:616–623. https://doi.org/10.1289/ehp.1307201 CrossRefGoogle Scholar
- Tapia-Conyer R, Gutiérrez G, Sepúlveda J (1992) Methodology of the National Seroepidemiologic Survey, Mexico. Salud Pública Mex 34:124–135Google Scholar
- Townsend MK, Franke AA, Li X, Hu FB, Eliassen AH (2013) Within-person reproducibility of urinary bisphenol A and phthalate metabolites over a 1 to 3 year period among women in the nurses ’ health studies : a prospective cohort study. Environ Health 12:1–9. https://doi.org/10.1186/1476-069X-12-80 CrossRefGoogle Scholar
- World Health Organization (2016) Global report on diabetes executive summary. WHO 1–4. ISBN 9789241565257Google Scholar