Environmental Science and Pollution Research

, Volume 26, Issue 20, pp 20148–20163 | Cite as

Graphene oxide as a tool for antibiotic-resistant gene removal: a review

  • Zuzana Bytesnikova
  • Lukas RichteraEmail author
  • Kristyna Smerkova
  • Vojtech Adam
Review Article


Environmental pollutants, including antibiotics (ATBs), have become an increasingly common health hazard in the last several decades. Overdose and abuse of ATBs led to the emergence of antibiotic-resistant genes (ARGs), which represent a serious health threat. Moreover, water bodies and reservoirs are places where a wide range of bacterial species with ARGs originate, owing to the strong selective pressure from presence of ATB residues. In this regard, graphene oxide (GO) has been utilised in several fields including remediation of the environment. In this review, we present a brief overview of resistant genes of frequently used ATBs, their occurrence in the environment and their behaviour. Further, we discussed the factors influencing the binding of nucleic acids and the response of ARGs to GO, including the presence of salts in the water environment or water pH, because of intrinsic properties of GO of not only binding to nucleic acids but also catalysing their decomposition. This would be helpful in designing new types of water treatment facilities.


Graphene oxide Antibiotics Nanomaterials Genes Wastewater Environment Pollution 



This work was financially supported by the Internal Grant Agency of Mendel University in Brno (IP 20/2017), by ERDF ‘Multidisciplinary research to increase application potential of nanomaterials in agricultural practice’ (No. CZ.02.1.01/0.0/0.0/16_025/0007314) and CEITEC 2020 (LQ1601).


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryMendel University in BrnoBrnoCzech Republic
  2. 2.Central European Institute of TechnologyBrno University of TechnologyBrnoCzech Republic

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