Environmental Science and Pollution Research

, Volume 26, Issue 17, pp 17110–17120 | Cite as

Assessment of the structural reorganization of liver and biochemical parameters of blood serum after introduction of zinc nanoparticles and its oxides

  • Elena SizovaEmail author
  • Sergey Miroshnikov
  • Xenia Nechitailo
Research Article


The demand for nanoparticles of metals and their oxides in medicine and biology is indisputable. To ensure the safe use of the unique capabilities of nanostructures, in particular, essential metals and their oxides, and to further search for ways leveling side effects of toxic effects in biomedical applications, a multifaceted approach to the study of their properties is needed, primarily affecting the effects on the organism level. In this connection, the purpose of the present research was to study the effect of zinc nanoparticles (ZnNPs) and zinc oxide nanoparticles (ZnONPs) on structural reorganization of the liver and morpho-biochemical parameters of rat blood. The test substances exhibit a hepatotoxic effect upon their single intraperitoneal administration to rats. In the experiment, increased activity of gamma glutamyltransferase (GGT) and lactate dehydrogenase (LDH), increased expression of caspase-3, the presence of signs of oxidative stress, inflammation, and capillary-trophic insufficiency, and induction of tumor necrosis factor (TNF-α), and colony stimulating factor 2 (granulocyte-macrophage) (GM-CSF) were registered in the experiment. The level of interferon-γ in the experimental groups tended to decrease in comparison with the control group. The observed effects progressed in time, most noticeably manifested in the case of ZnONPs. Comparing the dosages, ZnNPs are less toxic than ZnONPs.


Nanoparticles Zinc Apoptosis Oxidative stress Blood serum Liver Elemental composition Rats 



Research was done with financial support of the Russian Science Foundation # 14-16-00060-P.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Elena Sizova
    • 1
    Email author
  • Sergey Miroshnikov
    • 1
  • Xenia Nechitailo
    • 1
  1. 1.Federal Research Centre of Biological Systems and Agro-Technologies of the Russian Academy of SciencesOrenburg State UniversityOrenburgRussia

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