Advertisement

Association between particulate matter air pollution and cardiovascular disease mortality in Lanzhou, China

  • Tingting Wu
  • Yuan Ma
  • Xuan Wu
  • Ming Bai
  • Yu Peng
  • Weiting Cai
  • Yongxiang Wang
  • Jing Zhao
  • Zheng ZhangEmail author
Research Article
  • 73 Downloads

Abstract

Ambient particulate matter (PM) pollution has been linked to elevated mortality, especially from cardiovascular diseases. However, evidence on the effects of particulate matter pollution on cardiovascular mortality is still limited in Lanzhou, China. This research aimed to examine the associations of daily mean concentrations of ambient air pollutants (PM2.5, PMC, and PM10) and cardiovascular mortality due to overall and cause-specific diseases in Lanzhou. Data representing daily cardiovascular mortality rates, meteorological factors (daily average temperature, daily average humidity, and atmospheric pressure), and air pollutants (PM2.5, PM10, SO2, NO2) were collected from January 1, 2014, to December 31, 2017, in Lanzhou. A quasi-Poisson regression model combined with a distributed lag non-linear model (DLNM) was used to estimate the associations. Stratified analyses were also performed by different cause-specific diseases, including cerebrovascular disease (CD), ischemic heart disease (IHD), heart rhythm disturbances (HRD), and heart failure (HF). The results showed that elevated concentration of PM2.5, PMC, and PM10 had different effects on mortality of different cardiovascular diseases. Only cerebrovascular disease showed a significant positive association with elevated PM2.5. Positive associations were identified between PMC and daily mortality rates from total cardiovascular diseases, cerebrovascular diseases, and ischemic heart diseases. Besides, increased concentration of PM10 was correlated with increased death of cerebrovascular diseases and ischemic heart diseases. For cerebrovascular disease, each 10 μg/m3 increase in PM2.5 at lag4 was associated with increments of 1.22% (95% CI 0.11–2.35%). The largest significant effects for PMC on cardiovascular diseases and ischemic heart diseases were both observed at lag0, and a 10 μg/m3 increment in concentration of PMC was associated with 0.47% (95% CI 0.06–0.88%) and 0.85% (95% CI 0.18–1.52%) increases in cardiovascular mortality and ischemic heart diseases. In addition, it exhibited a lag effect on cerebrovascular mortality as well, which was most significant at lag6d, and an increase of 10 μg/m3 in PMC was associated with a 0.76% (95% CI 0.16–1.37%) increase in cerebrovascular mortality. The estimates of percentage change in daily mortality rates per 10 μg/m3 increase in PM10 were 0.52% (95% CI 0.05–1.02%) for cerebrovascular disease at lag6 and 0.53% (95% CI 0.01–1.05%) for ischemic heart disease at lag0, respectively. Our study suggests that elevated concentration of atmospheric PM (PM2.5, PMC, and PM10) in Lanzhou is associated with increased mortality of cardiovascular diseases and that the health effect of elevated concentration of PM2.5 is more significant than that of PMC and PM10.

Keywords

Air pollution Particulate matter Cardiovascular diseases Mortality Death Time-series study 

Abbreviations

CDC

Center for Disease Control and Prevention

CVD

Total cardiovascular disease

DLNM

Distributed lag non-linear model

GAM

Generalized additive model

ER

Excessive risk

RR

Relative risk

Notes

Acknowledgments

This study was supported by the Fundamental Research Funds for the Central Universities (lzujbky-2018-kb17).

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.

Supplementary material

11356_2019_4742_MOESM1_ESM.doc (3.4 mb)
ESM 1 (DOC 3.42 mb)

References

  1. Adar SD, Filigrana PA, Clements N, Peel JL (2014) Ambient coarse particulate matter and human health: a systematic review and meta-analysis. Curr Environ Health Rep 1(8):258–274CrossRefGoogle Scholar
  2. Bhaskaran K, Gasparrini A, Hajat S, Smeeth L, Armstrong B (2013) Time series regression studies in environmental epidemiology. Int J Epidemiol 42(4):1187–1195CrossRefGoogle Scholar
  3. Díaz J, Tobías A, Linares C (2012) Saharan dust and association between particulate matter and case-specific mortality: a case-crossover analysis in Madrid (Spain). Environ Health 11(3):11.  https://doi.org/10.1186/1476-069X-11-11 CrossRefGoogle Scholar
  4. Franklin M, Zeka A, Schwartz J (2007) Association between PM2.5 and all-cause and specific-cause mortality in 27 US communities. J Expo Sci Environ Epidemiol 17(3):279–287CrossRefGoogle Scholar
  5. Gasparrini A, Armstronga B, Kenwardb MG (2010) Distributed lag non-linear models. Stat Med 29(5):2224–2234CrossRefGoogle Scholar
  6. Gasparrini A (2011) Distributed lag linear and non-linear models in R: the package DLNM. J Stat Softw 43(8):1–20CrossRefGoogle Scholar
  7. Hong YC, Lee JT, Kim H, Ha EH, Schwartz J, Christiani DC (2002) Effects of air pollutants on acute stroke mortality. Environ Health Perspect 110(2):187–191CrossRefGoogle Scholar
  8. Kan H, Jia J, Chen B (2003) Acute stroke mortality and air pollution: new evidence from Shanghai, China. J Occup Health 45(5):321–323CrossRefGoogle Scholar
  9. Li G, Zhou M, Cai Y, Zhang Y, Pan X (2011) Does temperature enhance acute mortality effects of ambient particle pollution in Tianjin City, China. Sci Total Environ 409(10):1811–1817CrossRefGoogle Scholar
  10. Li L, Lin GZ, Liu HZ, Guo Y, Ou CQ, Chen PY (2015) Can the air pollution index be used to communicate the health risks of air pollution? Environ Pollut 205(10):153–160CrossRefGoogle Scholar
  11. Lin H, Liu T, Xiao J, Zeng W, Li X, Guo L, Zhang Y, Xu Y, Tao J, Xian H, Syberg KM, Qian Z, Ma W (2016) Mortality burden of ambient fine particulate air pollution in six Chinese cities: results from the Pearl River Delta study. Environ Int 96(3):91–97CrossRefGoogle Scholar
  12. Lu F, Zhou L, Xu Y, Zheng T, Guo Y, Wellenius GA, Bassig BA, Chen X, Wang H, Zheng X (2015) Short-term effects of air pollution on daily mortality and years of life lost in Nanjing, China. Sci Total Environ 536(12):123–129CrossRefGoogle Scholar
  13. Ma Y, Chen R, Pan G, Xu X, Song W, Chen B, Kan H (2011) Fine particulate air pollution and daily mortality in Shenyang, China. Sci Total Environ 409(13):2473–2477CrossRefGoogle Scholar
  14. Perez L, Medina-Ramón M, Künzli N, Alastuey A, Pey J, Pérez N, Garcia R, Tobias A, Querol X, Sunyer J (2009) Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, Spain. Environ Sci Technol 43(13):4707–4714CrossRefGoogle Scholar
  15. Qu DY, Zhou W, Chen LH, Wang J, Lu CY (2013) Pollution of PM2.5 and PM10 in the aerosol airborne (PM10, PM2.5) in Lanzhou. J Arid Land Resour Environ 27(1):70–74 (in Chinese)Google Scholar
  16. R Development Core Team (2014) R: A language and environment for statistical computing. R Foundation for Statistical Computing, ViennaGoogle Scholar
  17. Samet JM, Dominici F, Zeger SL, Schwartz J, Dockery DW (2000) The national morbidity, mortality, and air pollution study. Part I: methods and methodologic issues. Res Rep Health Eff Inst 94(2):5–14Google Scholar
  18. Venners SA, Wang B, Xu Z, Schlatter Y, Wang L, Xu X (2003) Particulate matter, sulfurdioxide, and daily mortality in Chongqing, China. Environ Health Perspect 111(4):562–567CrossRefGoogle Scholar
  19. Wang L, Kong L, Wu F, Bai Y, Burto R (2005) Preventing chronic diseases in China. Lancet 366(9499):1821–1824CrossRefGoogle Scholar
  20. Wang X, Chen R, Meng X, Geng F, Wang C, Kan H (2013) Associations between fine particle, coarse particle, black carbon and hospital visits in a Chinese city. Sci Total Environ 458–460:1–6CrossRefGoogle Scholar
  21. Wang X, Nie Y, Chen H, Wang B, Huang T, Xia DS (2016) Pollution characteristics and source apportionment of PM2.5 in Lanzhou City. Chin J Environ Sci 37(5):1619–1628 (in Chinese)Google Scholar
  22. Wang Y, Eliot MN, Wellenius GA (2014) Short-term changes in ambient particulate matter and risk of stroke: a systematic review and meta-analysis. J Am Heart Assoc 3(4):845–847Google Scholar
  23. Wong TW, Tam WS, Yu TS, Wong AH (2002) Associations between daily mortalities from respiratory and cardiovascular diseases and air pollution in Hong Kong, China. Occup Environ Med 59(1):30–35CrossRefGoogle Scholar
  24. Wu GP, Hu W, Teng EJ, Wei FS (1999) PM2.5 and PM10 pollution level in the four cities in China. China Environ Sci 19(2):133–137 (in Chinese)Google Scholar
  25. Xie H, Yao Z, Zhang Y, Xu Y, Xu X, Liu T, Lin H, Lao X, Rutherford S, Chu C, Huang C, Baum S, Ma W (2013) Short-term effects of the 2008 cold spell on mortality in three subtropical cities in Guangdong Province, China. Environ Health Perspect 121(2):210–216CrossRefGoogle Scholar
  26. Xie W, Li G, Zhao D, Xie X, Wei Z, Wang W, Wang M, Li G, Liu W, Sun J, Jia Z, Zhang Q, Liu J (2015) Relationship between fine particulate air pollution and ischaemic heart disease morbidity and mortality. Heart 101(4):257–263CrossRefGoogle Scholar
  27. Yorifuji T, Kawachi I, Sakamoto T, Doi H (2011) Associations of outdoor air pollution with hemorrhagic stroke mortality. J Occup Environ Med 53(2):124–126CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.The First Clinical Medical College of Lanzhou UniversityChengguan DistrictChina
  2. 2.Gansu Key Laboratory of Cardiovascular DiseaseChengguan DistrictChina
  3. 3.Department of Ultrasound in ChildrenThe Second Hospital of Lanzhou UniversityChengguan DistrictChina
  4. 4.Disease Control and Prevention Center in Chengguan DistrictLanzhouChina
  5. 5.Heart CenterThe First Hospital of Lanzhou UniversityChengguan DistrictChina

Personalised recommendations