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A mini review of bisphenol A (BPA) effects on cancer-related cellular signaling pathways

  • Samira Nomiri
  • Reyhane HoshyarEmail author
  • Concetta Ambrosino
  • Charles R. Tyler
  • Borhan MansouriEmail author
Review Article

Abstract

Bisphenol A (BPA) is a plasticizer used widely in many industrial products and is now well established as an endocrine-disrupting chemical (EDC). BPA readily leaches out from these products into the environment and into foodstuffs (from packaging materials) and human exposure can be considerable. Many studies have shown that BPA exposure is associated with a range of chronic human health conditions, including diabetes, cardiovascular disorders, polycystic ovarian disease, hepatotoxicity, and various types of cancer. BPA exerts its effects through deregulating cell signaling pathways associated with cell growth, proliferation, migration, invasion, and apoptosis. Previous studies on the molecular mechanisms of BPA have illustrated a variety of pathways impaired at very low exposure concentrations and that stimulate cellular responses relating to tumorigenesis both in cancer onset and progression. In this mini review, the recent advancements made through in vitro analyses are reported on for the effect of BPA on various cellular signaling pathways focusing on the signaling pathways that play a major role in carcinogenesis.

Keywords

Bisphenol A Cancer Signal pathway Toxicity 

Abbreviations

BPA

bisphenol A

EDCs

hormone-disrupting compounds

EPA

environmental protection agency

BW

body weight

Notes

Acknowledgment

The authors gratefully acknowledge the support from the Research Council of Birjand University of Medical Sciences. The contribution of the Cellular and Molecular Research Center and Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, is also sincerely appreciated.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Student Research CommitteeBirjand University of Medical SciencesBirjandIran
  2. 2.Cellular and Molecular Research Center, Clinical Biochemistry DepartmentBirjand University of Medical SciencesBirjandIran
  3. 3.Department of Microbiology and Molecular GeneticsMichigan State UniversityEast LansingUSA
  4. 4.Department of Science and TechnologyUniversity of SannioBeneventoItaly
  5. 5.IRGSBiogemAvellinoItaly
  6. 6.IEOS-CNRNaplesItaly
  7. 7.Biosciences, College of Life and Environmental SciencesUniversity of ExeterExeterUnited Kingdom
  8. 8.Medical Toxicology and Drug Abuse Research Center (MTDRC)Birjand University of Medical SciencesBirjandIran

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