Chronic mercury exposure and blood pressure in children and adolescents: a systematic review
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The aim of this paper is to systematically review the scientific literature on the possible relation of chronic mercury exposure and blood pressure among children and adolescents. We searched for observational studies in 6 electronic databases and grey literature for English, French or Spanish language studies published up to 30th November 2017. We performed a quality assessment of primary studies. We identified 8 articles involving 5 cohorts, 1 cross-sectional study and 1 case-control study. The participants had mean ages of between 3 and 17 years. Mercury was analysed in different matrices and periods of exposure. Four articles evaluated prenatal exposure, 2 evaluated both prenatal and postnatal exposures and 2 postnatal exposure. Blood pressure was measured according to different protocols. The association between mercury and blood pressure was adjusted by different covariates in each study. Four articles found a positive significant association between chronic mercury exposure and blood pressure in children or adolescents. Among these 4 articles, three of them evaluated prenatal exposure. There are still few studies assessing chronic mercury exposure and blood pressure in children and adolescents with inconsistency in results. Designs are very heterogeneous, which hampers their comparability. Evidence of this association is scarce and further research is needed.
KeywordsEnvironmental exposure Mercury Cardiovascular Blood pressure Paediatrics Public health Epidemiology
Diastolic blood pressure
Polyunsaturated fatty acids
Systolic blood pressure
Web of Science
We thank Beatriz Valera, Ph.D. for providing her manuscript and M. Francisca Abad, Ph.D. for her recommendations on databases and documentation.
All the authors participated in the conception of the article. Gema Gallego-Viñas designed the search strategy. Gema Gallego-Viñas and Sabrina Llop searched for and selected relevant articles. All the authors participated in data extraction, analysis and interpretation of data, drafting the article, and final approval of the version to be published.
This work was supported by Miguel Servet-FEDER (MS 15/0025) and FIS-FEDER (16_1288).
Compliance with ethical standards
The authors declare that they have no conflict of interest.
- Abad García MF, González Teruel A, Argento J, Rodríguez Gairín JM (2015) Characteristics and visibility of Spanish journals in Health Sciences and databases. Abad García María Francisca González Teruel Aurora M Argento Javier Rodríguez Gairín Josep Man 2015. Prof Inf 24(5):537–550. https://doi.org/10.3145/epi.2015.sep.04 (in Spanish)CrossRefGoogle Scholar
- Agency for Toxic Substances and Disease Registry (2018) Glossary of terms | ATSDR. https://www.atsdr.cdc.gov/glossary.html#G-A-. Accessed 28 Apr 2018
- Brady TM, Stefani-Glücksberg A, Simonetti GD (2018) Management of high blood pressure in children: similarities and differences between US and European guidelines. Pediatr Nephrol Berl Ger. https://doi.org/10.1007/s00467-018-3946-y
- Cascaes da Silva F, Arancibia V, Angélica B et al (2013) Evaluation lists and scales for the quality of scientific studies. Rev Cuba Inf En Cienc Salud 24:295–312 (in Spanish)Google Scholar
- Flynn JT, Kaelber DC, Baker-Smith CM et al (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140. https://doi.org/10.1542/peds.2017-1904
- Foraster M, Basagaña X, Aguilera I et al (2014) Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population-based cohort in Spain (the REGICOR study). Environ Health Perspect 122:404–411. https://doi.org/10.1289/ehp.1306497 CrossRefGoogle Scholar
- GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Lond Engl 390:1211–1259. https://doi.org/10.1016/S0140-6736(17)32154-2 CrossRefGoogle Scholar
- Genchi G, Sinicropi MS, Carocci A et al (2017) Mercury exposure and heart diseases. Int J Environ Res Public Health 14. https://doi.org/10.3390/ijerph14010074
- Hao Y, Wu B, Shi J et al (2011) Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China. Chin Med J 124:2113–2116Google Scholar
- Houston MC (2014) The role of mercury in cardiovascular disease. J Cardiovasc Dis Diagn 2014. https://doi.org/10.4172/2329-9517.1000170
- Joint FAO/WHO Expert Committee on Food Additives (JECFA) (2011) Safety evaluation of certain food additives and contaminants. Geneva, Switzerland. http://whqlibdoc.who.int/publications/2011/9789241660631_eng.pdf. Accessed 26 July 2016
- Kessler R (2013) The Minamata Convention on Mercury: a first step toward protecting future generations. Environ Health Perspect 121:A304–A309Google Scholar
- Lurbe E, Agabiti-Rosei E, Cruickshank JK et al (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. https://doi.org/10.1097/HJH.0000000000001039
- National Research Council (NRC) (2000) Toxicological effects of methylmercury. Academic Press, Washington, DCGoogle Scholar
- Poursafa P, Ataee E, Motlagh ME et al (2014) Association of serum lead and mercury level with cardiometabolic risk factors and liver enzymes in a nationally representative sample of adolescents: the CASPIAN-III study. Environ Sci Pollut Res Int 21:13496–13502. https://doi.org/10.1007/s11356-014-3238-4 CrossRefGoogle Scholar
- Roman HA, Walsh TL, Coull BA et al (2011) Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis. Environ Health Perspect 119:607–614. https://doi.org/10.1289/ehp.1003012 CrossRefGoogle Scholar
- Ruggieri F, Majorani C, Domanico F, Alimonti A (2017) Mercury in children: current state on exposure through human biomonitoring studies. Int J Environ Res Public Health 14. https://doi.org/10.3390/ijerph14050519
- Sundseth K, Pacyna JM, Pacyna EG et al (2017) Global sources and pathways of mercury in the context of human health. Int J Environ Res Public Health 14. https://doi.org/10.3390/ijerph14010105
- United Nations Environment Programme. (2013) Mercury: Time to act. Geneva, Switzerland: UNEP Chemicals Branch. http://cwm.unitar.org/cwmplatformscms/site/assets/files/1254/mercury_timetoact.pdf. Accessed 26 July 2016
- WHO (1991) Environmental Health Criteria 118. Inorganic Mercury. Switzerland, Geneva http://www.inchem.org/documents/ehc/ehc/ehc118.htm. Accessed 24 Apr 2018Google Scholar
- WHO (2010) Children’s exposure to mercury compounds. Switzerland, Geneva http://apps.who.int/iris/bitstream/handle/10665/44445/9789241500456_eng.pdf;jsessionid=06ED69CBBAF04FFD9FB778C8B308C141?sequence=1. Accessed 01 July 2017Google Scholar
- WHO (2013a) A global brief on hypertension. Silent killer, global public health crisis. Switzerland, Geneva http://apps.who.int/iris/bitstream/handle/10665/79059/WHO_DCO_WHD_2013.2_eng.pdf?sequence=1. Accessed 28 Apr 2018Google Scholar
- WHO (2013b) Mercury and health. Switzerland, Geneva http://www.who.int/en/news-room/fact-sheets/detail/mercury-and-health. Accessed 24 Apr 2018Google Scholar
- WHO-UNEP (2008) Guidance for identifying populations at risk from mercury exposure. Switzerland, Geneva https://wedocs.unep.org/bitstream/handle/20.500.11822/11786/IdentifyingPopnatRiskExposuretoMercury_2008Web.pdf?sequence=1&isAllowed=y. Accessed 25 June 2017Google Scholar